:Effect of Several Drugs on Gastric Mucus

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The properties of gastric covering mucus and epithelial mucus at the different segments of stomach were studied by the histochemical method. In addition, the mucous volume was investigated quantitatively by measuring the ratio between the thickness of mucous layer and mucosal layer.The oral administration of indomethacine and prednisolone to rats induced gastric mucosal injuries and decreased gastric mucous secretion, and it suggested a possible pathogenesis of drug induced ulceration. On the contrast, in prostaglandin E2, pirenzepine, and L-glutamine administered rats, the increase of gastric mucous secretion was observed suggesting the reinforcement of gastric mucous barrier.This method made it possible to investgate the gastric covering mucous layer and it seemed to be a very useful mean on the study of gastric mucus which is very important factor in the gastric mucosal protective mechanism.
財団法人日本消化器病学会の論文