Dexepin hydrochlorideの行動薬理学的研究

概要

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Doxepin was compared with amitriptyline and imipramine in respect to behavioral pharmacology with rats and mice. Doxepin antagonized reserpine hypothermia and tetrabenazine ptosis and potentiated amphetamine stereotypy and methamphetamine hyperactivity. In this respect doxepin and amitriptyline were equipotent but doxepin was more potent than amitriptyline and imipramine regarding major or minor tranquilizing-like effects, such as reduction of locomotor activity in open-field test, inhibition of conditioned avoidance response, suppression of experimentally induced hyperemotionality, anticonvulsant activity and potentiation of hypnotics and anesthetics. Doxepin is, therefore, characterized as an antidepressant drug having marked tranquilizing activities.
社団法人日本薬理学会の論文