Doxepin hydrochlorideの脳波学的研究

概要

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Electroencephalographic (EEG) effects of doxepin were compared with those of imipramine, amitriptyline, chlorpromazine and diazepam in unanesthetized, unrestrained rabbits and cats. 1) Doxepin induced high voltage fast waves in spontaneous EEG of the amygdala followed by a generalized drowsy pattern in all brain areas under behavioral sedation. 2) Doxepin suppressed the EEG arousal responses induced not only by photic or auditory stimulation but also by mesencephalic reticular and hypothalamic stimulation, whereas chlorpromazine blocked only the former without affecting the latter. 3) Doxepin facilitated the recruiting response and showed no effect on the photic driving response in the visual cortex. 4) Doxepin exerted a biphasic effect on the limbic afterdischarges elicited by either hippocampal or amygdaloid stimulation; i.e. Doxepin initially depressed them, as did diazepam, but thereafter enhanced them as did chlorpromazine. These EEG effects of doxepin were qualitatively similar to those of imipramine and amitriptyline, but different from those of chlorpromazine and diazepam.
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