The Regulation of Ovarian Granulosa Cell Death by Pro- and Anti-apoptotic Molecules
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概要
- 論文の詳細を見る
In the mammalian ovary, follicular development and atresia are closely regulated by cell death and survival-promoting factors, including hormones (gonadotropins) and intraovarian regulators (gonadal steroids, cytokines, and intracellular proteins). Several hundred thousand primordial follicles are present in the mammalian ovary; however, only a limited number of primordial follicles develop to the preovulatory stage and ovulate. The others, more than 99% of follicles, will be eliminated via a degenerative process known as "atresia." The endocrinological regulatory mechanisms involved in follicular development and atresia have been characterized to a large extent, but the precise temporal and molecular mechanisms involved in the regulation of these events have remained largely unknown. Recent studies suggest that the apoptosis of ovarian granulosa cells plays a major role in follicular atresia. In this review, we provide an overview of development and atresia of follicles, and apoptosis of granulosa cells in mammals.
- 日本繁殖生物学会の論文
- 2006-12-01
著者
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MANABE Noboru
Research Unit of Animal Life Sciences, Animal Resource Science Centre, The University of Tokyo
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Inoue Naoko
Laboratory Of Animal Morphology And Function Graduate School Of Bioagricultural Sciences Nagoya Univ
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Manabe Noboru
Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo
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Manabe Noboru
Animal Resource Science Center The University Of Tokyo
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GOTO Yasufumi
Animal Resource Science Center, The University of Tokyo
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GOTO Yasufumi
Research Unit for Animal Life Sciences, Animal Resource Science Center, Graduate School of Agricultu
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MATSUDA MINEHATA
Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
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Matsuda Fuko
東京大学大学院農学生命科学研究科高等動物教育研究センター附属牧場
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Manabe Noboru
Animal Resource Sci. Center Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Matsuda F
Univ. Tokyo Tokyo Jpn
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Inoue Naoko
Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University
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Manabe Noboru
Research Center For Food Safety Graduate School Of Agricultural And Life Sciences The University Of
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Goto Yasufumi
Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura
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Matsuda-minehata Fuko
Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura
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Inoue Naoko
Laboratory Of Animal Morphology And Function Division Of Biofunctional Development Graduate School Of Bioagricultural Sciences Nagoya University
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