Changes in Expression and Localization of GPRC5B and RARα in the Placenta and Yolk Sac During Middle to Late Gestation in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The mRNA expression of GPRC5B, an orphan G protein-coupled receptor, is induced by retinoic acid (RA). Because RA plays critical roles in embryonic development, reproductive functions, metabolism and homeostasis, GPRC5B is also considered crucial in these physiological events. We investigated the changes in expression of GPRC5B and RA receptor (RAR) α mRNAs and immunohistochemical localization of their proteins in the murine placenta and yolk sac at 13.5, 15.5 and 17.5 days post coitus. Stable levels of GPRC5B and RARα mRNAs were detected in the placenta and yolk sac. In the placenta, GPRC5B was present in maternal and fetal vascular endothelial cells, stromal cells, fibroblast-like cells and glycogen cells. A strong reaction to RARα was detected in maternal and fetal vascular endothelial cells and stromal cells. The levels of GPRC5B and RARα proteins in maternal and fetal vascular endothelial cells decreased with gestation. In the yolk sac, GPRC5B and RARα proteins were detected in vascular endothelial cells, but their levels did not change during the gestation period. These findings indicate that GPRC5B is involved in RA-dependent morphogenesis/angiogenesis and regulation of extracellular matrix synthesis in the murine placenta and yolk sac.
- 日本繁殖生物学会の論文
- 2007-10-01
著者
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Sugimoto Miki
Graduate School of Agriculture, Kyoto University
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Morita Maki
Graduate School of Agriculture, Kyoto University
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MANABE Noboru
Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of
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Morita M
Graduate School Of Agriculture Kyoto University
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Morita Maki
Department Of Anesthesiology Kasugai Municipal Hospital
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Sugimoto Miki
国立環境研究所 環境リスク研究プログラム
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Sugimoto Miki
Graduate School Of Agriculture Kyoto University
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Manabe Noboru
Animal Resource Center The University Of Tokyo:research Center. For Food Safety The University Of To
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Manabe Noboru
Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo
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SUGIMOTO Miki
Department of Animal Sciences, Kyoto University
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Manabe Noboru
Animal Resource Science Center The University Of Tokyo
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IMANISHI Satoshi
Health Risk Research Section, Research Center for Environmental Risk, National Institute for Environ
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KUME Shinichi
Department of Animal Sciences, Kyoto University
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Kume Shinichi
Department Of Animal Production Hokkaido National Agricultural Experiment Station
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Manabe Noboru
Animal Resource Sci. Center Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Sugimoto Miki
京都大学 農学研究科
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Sugimoto Miki
Department Of Animal Science Faculty Of Agriculture Kyoto University
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Morita Maki
Department Of Anesthesiology And Critical Care Medicine Kasugai Municipal Hospital
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Sugimoto Miki
Department Of Animal Sciences Kyoto University
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Imanishi S
Laboratory Of Animal Physiology And Functional Anatomy Graduate School Of Agriculture Kyoto Universi
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Sugimoto Miki
Laboratory Of Animal Physiology And Functional Anatomy Graduate School Of Agriculture Kyoto University
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