Molecular Cloning of Porcine (Sus scrofa) Tumor Necrosis Factor Receptor 2

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概要

• 論文の詳細を見る

• Tumor necrosis factor (TNF) α can induce both cell death and proliferation by binding to either TNF receptor (TNFR) 1 or 2. In the granulosa cells of porcine ovaries, TNFα is considered to act as an anti-apoptotic/survival factor during follicular atresia. As a first step toward elucidating the function of TNFR2 in regulating follicular development/growth and atresia in porcine ovaries, we isolated the porcine (Sus scrofa) cDNA encoding TNFR2, which was identified from a cDNA library prepared from the follicular granulosa cells of pig ovaries. Porcine TNFR2 (1,125 bp, 375 amino acid residues), which contains specific amino acid region of transmembrane, indicated high identities with human and murine TNFR2 (78 and 69% at mRNA level, respectively; 73 and 61% at protein level, respectively), suggesting that the function of porcine TNFR2 is similar to that of human and murine homologues. Understanding the expression patterns of porcine TNFR2 mRNA in various organs, which we confirmed by reverse transcription polymerase chain reaction analysis, would help to elucidate the physiological role of TNFR2 in the regulation of apoptosis in porcine organs.

• 日本繁殖生物学会の論文
• 2007-12-01

著者

• MANABE Noboru

  Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of

• Manabe Noboru

  Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo

• Manabe Noboru

  Animal Resource Center The University Of Tokyo:research Center. For Food Safety The University Of To

• Manabe Noboru

  Graduate School Of Agricultural And Life Sciences University Of Tokyo

• Manabe Noboru

  Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo

• Manabe Noboru

  Animal Resource Science Center The University Of Tokyo

• CHENG Yuan

  Animal Resource Science Center, The University of Tokyo

• MAEDA Akihisa

  Animal Resource Science Center, The University of Tokyo

• GOTO Yasufumi

  Animal Resource Science Center, The University of Tokyo

• MATSUDA MINEHATA

  Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, University of Tok

• Cheng Yuan

  Animal Resource Science Center The University Of Tokyo

• Matsuda Fuko

  東京大学大学院農学生命科学研究科高等動物教育研究センター附属牧場

• Manabe Noboru

  Animal Resource Sci. Center Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• Matsuda F

  Univ. Tokyo Tokyo Jpn

• Maeda Akihisa

  Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura

• Goto Yasufumi

  Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura

• Matsuda-minehata Fuko

  Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura

• Maeda Akihisa

  Animal Resource Science Center The University Of Tokyo

• Goto Yasufumi

  Animal Resource Science Center The University Of Tokyo

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