Molecular Cloning of a Porcine (Sus scrofa) Apoptosis Inhibitory Ligand, Netrin-1, and Its Receptor, p53RDL1
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概要
- 論文の詳細を見る
The apoptosis inhibitory ligand, Netrin-1, and its receptor (p53-regulated receptor for death and life: p53RDL1) play an important role in the regulation of selective apoptosis. When Netrin-1 binds to p53RDL1, p53-dependent apoptosis is inhibited. We identified porcine (Sus scrofa) cDNAs encoding Netrin-1 [pNetrin-1; 1,803 base pairs (bp) and 600 amino acids (aa)] and p53RDL1 (pp53RDL1; 2,838 bp and 945 aa). Porcine p53RDL1 (pp53RDL1) contains a death domain (DD), a tandem specific amino acid region, in its C-terminal, suggesting that it mediates death signaling by binding with other pro-apoptotic factors via the DD. Porcine Netrin-1 (pNetrin-1), pp53RDL1 and the DD in pp53RDL1 showed high levels of identity in aa sequence with human and murine Netrin-1 (98 and 97%, respectively), p53RDL1 (94 and 91%, respectively) and the DD in p53RDL1 (96 and 95%, respectively). Reverse transcription-polymerase chain reaction (RT-PCR) revealed that the levels of pNetrin-1 and pp53RDL1 mRNAs were moderate in granulosa cells compared with their expression in other tissues and that their levels during follicular atresia were stable. The Netrin-1 and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells.
- 2008-08-01
著者
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MANABE Noboru
Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of
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Inoue Naoko
Laboratory Of Animal Morphology And Function Graduate School Of Bioagricultural Sciences Nagoya Univ
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NAKAGAWA Shoma
Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Manabe Noboru
Animal Resource Center The University Of Tokyo:research Center. For Food Safety The University Of To
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Manabe Noboru
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Manabe Noboru
Animal Resource Science Center Graduated School Of Agriculture And Life Science University Of Tokyo
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Manabe Noboru
Animal Resource Science Center The University Of Tokyo
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CHENG Yuan
Animal Resource Science Center, The University of Tokyo
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MAEDA Akihisa
Animal Resource Science Center, The University of Tokyo
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GOTO Yasufumi
Animal Resource Science Center, The University of Tokyo
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MATSUDA Fuko
Animal Resource Science Center, The University of Tokyo
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GONDA Hiroshi
Animal Resource Science Center, The University of Tokyo
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Cheng Yuan
Animal Resource Science Center The University Of Tokyo
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Matsuda Fuko
東京大学大学院農学生命科学研究科高等動物教育研究センター附属牧場
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Gonda Hiroshi
Animal Resource Science Center The University Of Tokyo
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Nakagawa S
Animal Resource Science Center The University Of Tokyo
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Manabe Noboru
Animal Resource Sci. Center Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Matsuda F
Univ. Tokyo Tokyo Jpn
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Inoue Naoko
Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University
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Maeda Akihisa
Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura
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Goto Yasufumi
Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura
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Matsuda-minehata Fuko
Research Unit For Animal Life Sciences Animal Resource Science Center Graduate School Of Agricultura
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Nakagawa Shoma
Animal Resource Science Center Graduate School Of Agricultural And Life Sciences The University Of T
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Maeda Akihisa
Animal Resource Science Center The University Of Tokyo
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Goto Yasufumi
Animal Resource Science Center The University Of Tokyo
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Inoue Naoko
Laboratory Of Animal Morphology And Function Division Of Biofunctional Development Graduate School Of Bioagricultural Sciences Nagoya University
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