造血細胞移植後のホーミングにおけるMAdCAM-1およびそのリガンドの役割

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概要

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• We examined the expression of VCAM-1 and MAdCAM-1 after bone marrow transplantation (BMT). We also examined the influence of α4β7 integrin blockade on the homing of cells to the bone marrow and spleen. The expression of VCAM-1 and MAdCAM-1 by endothelial cells in the spleen and bone marrow was examined by immunoelectron microscopy using colloidal gold and was analyzed semiquantitatively. To examine the role of α4β7 integrin in donor cells, a homing assay was conducted following α4β7 integrin blockade in bone marrow-derived hematopoietic cells or spleen colony cells. Immediately after BMT, the expression of VCAM-1 and MAdCAM1 markedly decreased, but expression recovered significantly between 12 and 24 h after BMT. VCAM-1 recovered more acutely than MAdCAM-1 from 12 h onward. In the group transplanted with anti-α4β7 integrin antibody-treated bone marrow cells, the numbers of homing cells in the spleen and bone marrow were significantly decreased in an antibody dose-dependent manner. However, the number of homing cells was not different in either the spleen or bone marrow between anti-α4β7 integrin antibody treated and untreated spleen colony cells. It has been reported that α4β1 integrin and its receptor VCAM-1 play major roles in the homing of hematopoietic cells to bone marrow. Our study indicates the importance of MAdCAM-1 and its ligand, α4β7 integrin, in the homing of bone marrow-derived hematopoietic cells, but not spleen colony-derived cells, to both the spleen and bone marrow.

著者

• 井上 直子

  京都大学農学研究科応用生物科学専攻生体機構学

• 多田 達哉

  名古屋大学大学院生命農学研究科動物形態情報学研究室

• 井上 直子

  名古屋大学大学院生命農学研究科動物形態情報学研究室

• WIDAYATI Diah

  Faculty of Animal Science, Gadjah Mada University

• Inoue Naoko

  Laboratory Of Animal Morphology And Function Graduate School Of Bioagricultural Sciences Nagoya Univ

• 井上 直子

  Laboratory of Animal Morphology and Function, Graduate School of Bioagricultural Sciences, Nagoya Un

• Fukuta Katsuhiro

  Laboratory of Animal Morphology and Function, Graduate School of Bioagricultural Sciences, Nagoya Un

• 多田 達哉

  Laboratory of Animal Morphology and Function, Graduate School of Bioagricultural Sciences, Nagoya Un

• FUKUTA Katsuhiro

  National Institute of Animal Health

• Fukuta Katsuhiro

  Laboratory Of Animal Morphology And Function Graduate School Of Bioagricultural Sciences Nagoya Univ

• Fukuta Katsuhiro

  Graduate School Of Bioagricultural Sciences Nagoya University

• TADA Tatsuya

  Laboratory of Animal Morphology and Function, Graduate School of Bioagricultural Sciences, Nagoya Un

• Fukuta K

  Nagoya Univ. Nagoya

• Fukuta Katsuhiro

  Lab. Of Animal Morphology And Function Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Widayati Diah

  Faculty Of Animal Science Gadjah Mada University

• Widayati Diah

  Laboratory Of Animal Morphology And Function Graduate School Of Bioagricultural Sciences Nagoya Univ

• TADA Tatsuya

  Laboratory of Animal Morphology and Function, Graduate School of Bioagricultural Sciences, Nagoya University

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