ICGNマウスにおける組織トランスグルタミナーゼ(tTG)の局在
スポンサーリンク
概要
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ICR-derived glomerulonephritis (ICGN) mice are a known inbred strain with hereditary nephrotic syndrome and are considered a good animal model of human idiopathic nephrotic syndrome. ICGN mice show proteinuria at a young age, and hypoalbuminemia, hyperlipidemia, anemia and edema accompanies their symptoms with aging. In addition, ICGN mice develop severe anemia with the progression of renal fibrosis similar to human chronic kidney disease (CKD). Recently, tissue transglutaminase (tTG) has been shown to be related to the renal fibrosis in several animal models and CKD patients. In the present study, we investigated the relationship between the progression of renal fibrosis and the localization of tTG in the kidneys using histochemistry and image analysis. Male ICGN mice aged 26-43 weeks were used. They were divided into two groups of early and terminal stages of renal fibrosis, based on plasma levels of blood urea nitrogen (BUN). Normal ICR males aged 11 weeks were used as a control group. tTG was localized to the interstitium in the normal ICR mice. In the early stage of renal fibrosis, the localization of tTG increased in renal tubules showing luminal dilation, as well as in the interstitium; however, the amount of tubular and interstitial tTG decreased in the late stage. In the glomeruli, tTG-immunoreactivity decreased in the late stage of renal fibrosis, despite the progression of glomerular sclerosis. The results suggest that ε(γ-glutamyl) lysine cross-linking is not directly related to the progression of renal fibrosis in ICGN mice.
- 社団法人 日本実験動物学会の論文
著者
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MANABE Noboru
Research Unit of Animal Life Sciences, Animal Resource Science Centre, The University of Tokyo
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宮本 庸平
東レ 医薬研究所安全性研究室
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宮本 庸平
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries
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妙本 陽
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries
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阪口 有佳
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries
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YAMAGUCHI-YAMADA Misuzu
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University
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UCHIO-YAMDA Kozue
Laboratory of Experimental Animal Models, National Institute of Biomedical Innovation
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MIYAMOTO Yohei
Toxicology Laboratory, Pharmaceutical Research Laboratories, Toray Industries, Inc.
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SAKAGUCHI Yuka
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries
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Miyamoto Yohei
Toxicology And Pharmacokinetics Laboratories Pharmaceutical Res. Laboratories Toray Industries Inc.
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MYOMOTO Akira
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries
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Sakaguchi Yuka
Toxicology And Pharmacokinetics Laboratories Pharmaceutical Research Laboratories Toray Industries I
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Manabe Noboru
Research Center For Food Safety Graduate School Of Agricultural And Life Sciences The University Of
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MANABE Noboru
Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
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MYOMOTO Akira
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc.
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