Effect of Human Erythropoietin (hEPO) Treatment on Anemia in ICR-derived Glomerulonephritis (ICGN) Mice
スポンサーリンク
概要
- 論文の詳細を見る
ICR-derived glomerulonephritis (ICGN) mice are a novel inbred strain with hereditary nephrotic syndrome and are thus considered a good animal model of human idiopathic nephrotic syndrome. In the present study, we investigated the effect to erythrocyte production by human erythropoietin (hEPO) treatment in ICGN mice during the early nephrotic stage. Erythrocyte count, hemoglobin concentration and hematocrit value in hEPO-treated (5 U/body/day, for 5 days) ICGN mice were recovered to the levels found in normal ICR mice. In addition, there was no correlation between plasma creatinine level, a marker of renal function, and erythrocyte count after hEPO treatment. Therefore, anemia in ICGN mice may be caused by decreased production of EPO in the kidney following progressive parenchymal damage.
- 社団法人 日本実験動物学会の論文
- 2005-04-01
著者
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Ogura Atsuo
Bioresource Center Riken
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Manabe Noboru
Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University
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MIYAMOTO Yohei
Toxicology Laboratory, Pharmaceutical Research Laboratories, Toray Industries, Inc.
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KURAMITSU MIYAMOTO
Toxicology Laboratory, Pharmaceutical Research Laboratories, Toray Industries, Inc.
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IWANAGA Ema
Toxicology Laboratory, Pharmaceutical Research Laboratories, Toray Industries, Inc.
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UCHIO YAMADA
Unit of Anatomy and Cell Biology, Department of Animal Sciences, Kyoto University
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YAMAGUCHI YAMADA
Unit of Anatomy and Cell Biology, Department of Animal Sciences, Kyoto University
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Uchio Yamada
Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University
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Iwanaga Ema
Toxicology And Pharmacokinetics Laboratories Pharmaceutical Research Laboratories Toray Industries I
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Iwanaga Ema
Toxicology Laboratory Pharmaceutical Research Laboratories Toray Industries Inc.
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Yamaguchi Yamada
Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University
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Kuramitsu Miyamoto
Toxicology Laboratory Pharmaceutical Research Laboratories Toray Industries Inc.
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Miyamoto Yohei
Toxicology And Pharmacokinetics Laboratories Pharmaceutical Res. Laboratories Toray Industries Inc.
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Miyamoto Yohei
Toxicology Laboratory Pharmaceutical Research Laboratories Toray Industries Inc.
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Kuramitsu-Miyamoto Keiko
Toxicology Laboratory, Pharmaceutical Research Laboratories, Toray Industries, Inc.
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