Spontaneous Accumulation of Globotriaosylceramide (Gb3) in Proximal Renal Tubules in an ICR Mouse
スポンサーリンク
概要
- 論文の詳細を見る
This report describes spontaneous cytoplasmic vacuolation in the proximal renal tubules of a 7-week-old male ICR [Crlj:CD1(ICR)] mouse. The contents of vacuoles were positively stained with periodic acid-Schiff (PAS) and Sudan black, and the membranes were positive on immunohistochemical staining for lysosomal-associated membrane protein-2 (LAMP-2), a marker of lysosomal membrane. Electron microscopy revealed electron-dense lamellar bodies in the proximal tubular epithelial cells. These histopathological features are similar to those in α-galactosidase A-deficient mice, in which globotriaosylceramide (Gb3), a glycosphingolipid, accumulates in lysosomes. When we performed immunohistochemical staining for Gb3, the contents of vacuoles were positively stained. From these results, spontaneous cytoplasmic vacuolation in the proximal renal tubules in the mouse was identified as lysosomal accumulation of Gb3.
- 日本毒性病理学会の論文
著者
-
Miyamoto Yohei
Toxicology And Pharmacokinetics Laboratories Pharmaceutical Res. Laboratories Toray Industries Inc.
-
Miyoshi Tomoya
Toxicology And Pharmacokinetics Laboratories Pharmaceutical Research Laboratories Toray Industries Inc.
-
Togashi Yuko
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro,Kamakura, Kanagawa 248-8555, Japan
-
Mutsuga Mayu
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro,Kamakura, Kanagawa 248-8555, Japan
-
Asaoka Yoshiji
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro,Kamakura, Kanagawa 248-8555, Japan
-
Imura Naoko
Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro,Kamakura, Kanagawa 248-8555, Japan
関連論文
- A protein assay for heme oxygenase-1 (HO-1) induced by chemicals in HepG2 cells
- An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry
- ICGNマウスにおける組織トランスグルタミナーゼ(tTG)の局在
- Effect of Human Erythropoietin (hEPO) Treatment on Anemia in ICR-derived Glomerulonephritis (ICGN) Mice
- CISPLATIN (CDDP)-INDUCED ACUTE TOXICITY IN AN EXPERIMENTAL MODEL OF HEPATIC FIBROSIS
- (-)-Epigallocatechin 3-O-gallate (EGCG) -induced apoptosis in normal rat kidney interstitial fibroblast (NRK-49F) cells
- CELLULAR TOXICITY OF CATECHIN ANALOGUES CONTAINING GALLATE IN OPOSSUM KIDNEY PROXIMAL TUBULAR (OK) CELLS
- P-55 Immunohistochemical Localization of Secretin, Cholecystokinin (CCK) and Somatostatin in The Rat Small Intestines after Acute CDDP Treatment
- Scratching Behavior of ICR-Derived Glomerulonephritis (ICGN) Mice
- P-84 Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated Dose Studies in Rats. : 1)2 Weeks Peroral Toxicity Study on Ethynylestradiol.(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 2)TESTICULAR TOXICITY IN RATS TREATED ORALLY WITH ETHINYLESTRADIOL FOR 2 WEEKS
- Focused DNA microarray analysis for sex-dependent gene expression of drug metabolizing enzymes, transporters and nuclear receptors in rat livers and kidneys
- A Novel Vitamin K1 2,3-Epoxide Reductase (VKOR) Inhibitor, 3-Acetyl-5-Methyltetronic Acid, Reduces Experimental Glomerulonephritis
- Spontaneous Accumulation of Globotriaosylceramide (Gb3) in Proximal Renal Tubules in an ICR Mouse