Molecular and Genetic Studies of Fusarium Trichothecene Biosynthesis: Pathways, Genes, and Evolution

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概要

• 論文の詳細を見る

• Trichothecenes are a large family of sesquiterpenoid secondary metabolites of Fusarium species (e.g., F. graminearum) and other molds. They are major mycotoxins that can cause serious problems when consumed via contaminated cereal grains. In the past 20 years, an outline of the trichothecene biosynthetic pathway has been established based on the results of precursor feeding experiments and blocked mutant analyses. Following the isolation of the pathway gene Tri5 encoding the first committed enzyme trichodiene synthase, 10 biosynthesis genes (Tri genes; two regulatory genes, seven pathway genes, and one transporter gene) were functionally identified in the Tri5 gene cluster. At least three pathway genes, Tri101 (separated alone), and Tri1 and Tri16 (located in the Tri1-Tri16 two-gene cluster), were found outside of the Tri5 gene cluster. In this review, we summarize the current understanding of the pathways of biosynthesis, the functions of cloned Tri genes, and the evolution of Tri genes, focusing on Fusarium species.

• 社団法人 日本農芸化学会の論文

著者

• FUJIMURA Makoto

  Faculty of Life Sciences, Toyo University

• KIMURA Makoto

  Plant & Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN

• Kimura M

  Laboratory Of Biochemistry Faculty Of Agriculture Graduate School Kyushu University

• Fujimura Makoto

  Faculty Of Life Sciences Toyo University

• OHSATO Shuichi

  Laboratory for Remediation Research, Plant Science Center, RIKEN

• TOKAI Takeshi

  Plant & Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN

• TAKAHASHI-ANDO Naoko

  Plant & Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN

• Kimura Makoto

  Plant & Microbial Metabolic Engineering Research Unit Discovery Research Institute (dri) Riken

• Tokai Takeshi

  Plant & Microbial Metabolic Engineering Research Unit Discovery Research Institute (dri) Riken

• Ohsato Shuichi

  Laboratory For Remediation Research Plant Science Center (psc1) Riken

• TAKAHASHI-ANDO Naoko

  Plant & Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN

• Tokai Takeshi

  Plant & Microbial Metabolic Engineering Research Unit, Discovery Research Institute (DRI), RIKEN

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