20315 体外循環用使い捨て磁気浮上遠心血液ポンプの開発(人工臓器と医用工学(4),OS.8 人工臓器と医用工学)

概要

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A disposable extracorporeal centrifugal blood pump utilizing a simply-structured radial controlled magnetic bearing and a torque transmission mechanism has been developed to enhance the durability of the disposable pump head and to reduce blood trauma such as hemolysis and thrombus formation. The prototype blood pump satisfied a requirement of a flow rate of 5 L/min against a head pressure of 800 mmHg. Under sinusoidal base excitation of the maximum acceleration of 9.8 m/s^2 from 10 to 200 Hz and impulse base excitation of 78.4 m/s^2 in the axial and radial directions, the impeller could levitate stably within amplitude of 35 μm in the radial direction, which was smaller than the fluid gaps of 0.3 mm. The normalized index of hemolysis of the prototype was 5.4 ± 0.8 mg/100L, which was about a half of the equivalent value of a commercialized pump having mechanical bearings (BioPump BPX-80). After in-vivo studies with calves for one to two weeks, no thrombus formation was found inside the pump heads.
2009-03-05