血液内科領域におけるボリコナゾール血中濃度測定の臨床的意義

概要

論文の詳細を見る
To promote the proper use of voriconazole (VRCZ), we monitored VRCZ blood concentrations, and investigated the clinical significance of doing this. On comparing C/D (blood VRCZ concentration/VRCZ dose) values for different VRCZ administration methods we found that there was no significant difference between the intravenous drip and oral administration methods (t-test : P=0.607) in this respect. There was also no correlation between the dose of VRCZ per unit body weight and its blood concentration (variance analysis : R^2=0.012, P=0.449). Though total bilirubin (T-Bil) levels were correlated with C/D values (variance analysis : R^2=0.104, P=0.020), serum creatinine clearance (CCr) and C/D values (variance analysis : R^2=0.062, P=0.078) were not correlated. Furthermore, C/D values in males were significantly higher than those in females (t-test : P=0.001). Approximately 25% of the patients had a blood concentration trough value exceeding 4.5μg/mL, which indicates an enhanced risk of liver dysfunction, and this suggests that the measurement of blood VRCZ concentrations is clinically important for preventing side effects.
日本医療薬学会の論文
2008-07-10