桂皮酸の輸液セットへの収着に与える pH の影響

概要

論文の詳細を見る
The purpose of this study was to investigate the relationship between the amount absorbed and the partition coefficient by using cinnamic acid in solutions with various pH solution. Cinnamic acid concentrations were measured by high-performance liquid chromatography. The partition coefficient of cinnamic acid between water and diethylhexyl phthalate, used as a plasticizer in polyvinyl chloride of the administration set, were measured at 30°C. The equilibrium absorbed amount of cinnamic acid was influenced by the pH of solutions. When the cinnamic acid concentration was 75 μg/ml in aqueous solutions, it was 1.05 mg/g at pH 1.23 and decreased to 0.63 mg/g at pH 3.96. And the calculated amount of cinnamic acid absorbed supposing that the equilibrium absorbed amount was in proportion to the apparent partition coefficient, was in good accordance with the experimental data.
公益社団法人日本薬学会の論文
1988-11-25