輸液セット中での硝酸イソソルビド溶液の含量低下(II) : ニトログリセリン溶液との比較

概要

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In the previous paper^<1)>, the mechanism of isosorbide dinitrate (ISDN) loss into the administration set was studied from equilibrium and kinetic approaches. The purpose of this study was to define the factors effecting the loss of nitroglycerin (GTN) from intravenous solutions and then to compare the results with those of ISDN loss described in the previous paper ISDN and GTN concentrations were measured by high-performance liquid chromatography. It was found that the factors effecting the loss of GTN were the containers, the length of administration set and the flow rate of intravenous solutions. When the GTN solutions was passed through the administration set at a flow rate of 1.38 ml/min, the largest decrease in GTN concentration occurred after 5 minutes. And these findings agreed well with the results of ISDN solutions. However, the loss of GTN from solutions after passage through the administration set was about twice larger than that of ISDN, because the rate of adsorption of GTN was much faster than that of ISDN.
日本医療薬学会の論文
1986-08-20