輸液セットへの収着によるフルニトラゼパムの含量低下

概要

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The loss of flunitrazepam from solutions into the intravenous delivery system was investigated. A linear relationship was found between the absorbed amount of flunitrazepam by the administration set and the equilibrium concentration within the range of 4.0-20.0μg/ml. At the flunitrazepam concentration of 10μg/ml in isotonic sodium chloride solution, the absorbed amount in equilibrium was 1.7mg/g and this value was about 50% of that of diazepam. When the solution was stored in a glass or polypropylene container no drug loss was observed while in a polyvinyl chloride bag flunitrazepam concentration was reduced to 54.8% in 24hr. When the flunitrazepam solution was passed through the administration set at a flow rate of 0.55ml/min, initial concentration 20μg/ml and the length of administration set 100cm, the flunitrazepam concentration at the outlet was reduced to 62.7% in 10 min, and gradually returned to the initial level with time.
日本医療薬学会の論文
1989-10-20