点滴中のミコナゾール注射液の含量低下

概要

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We investigated the loss of miconazole from solutions into the intravenous delivery system by equilibrium and kinetic approaches, Miconazole concentrations were measured by high-performance liquid chromatography. It was estimated that the loss of miconazole occurred through the mechanism of sorption, or partition and diffusion into the administration set. When the miconazole solution was passed through the administration set 100cm in length at a flow rate 0.81ml/min, and initial concentration 102μg/ml, the miconazole concentration was reduced to 79% in 15min. The factors affecting the loss of miconazole from intravenous solutions were the container materials, the concentration of miconazole injection and the pH of intravenous solutions. And the dissolution of diethylhexyl phthalate (DEHP), used as a plasticizer of the polyvinyl chloride (PVC), into the miconazol injection from the administration set was observed.
日本医療薬学会の論文
1992-08-20