ミダゾラムのプラスチック容器あるいは輸液セットへの収着に与えるpHの影響

概要

論文の詳細を見る
The mechanism of midazolam loss into a polyvinyl chloride(PVC) bag or an administration set was investigated in equilibrium and kinetic studies. When the buffer solution of midazolam stored in a glass or polyproPylene container no drug loss was observed, but in a PVC bag the amount of midazolam remaining in the solution was reduced as storage prolonged. After 24 hrs, nearly 53.8% of midazolam was sorbed into the bag at pH 6.0. A linear relation was found between the amount of midazolam sorbed into an administration set and the equilibrium concentration of midazolam in the range of 4〜20μg/ml at 30℃. The amount of midazolam sorbed into an administration set was influenced by the pH of the solution, When the midazolam concentration was 15μg/ml in aqueous solution, it was 0.45mg/g at pH 5.O and was increased to 5.24mg/g at pH 7.0. The calculated amount of sorbed midazolam, supposing that the equilibrium sorbed amount was in proportion to the apparent partition coefficients [diethylhexyl phthalate(DEHP)/water], was in good accordance with the experimental data. We estimated that midazolam loss into a PVC bag or an administration set occurred through partition and diffusion of midazolam to DEHP used as a plasticizer of PVC.
日本医療薬学会の論文
1992-10-20