輸液セット中でのシクロスポリンの含量低下

概要

論文の詳細を見る
The loss of cyclosporine from solutions into the intravenous delivery system was investigated. Concentration of cyclosporine was measured with high-performance liquid chromatography. When the cyclosporine solution was passed through the administration set 100cm in length at a flow rate 0.58ml/min, and initial concentration 49.5μg/ml, the concentration of cyclosporine was reduced to about 86% in 15 min, and gradually returned to the initial level with time. With the solutions stored in a glass or a polypropylene container no drug loss was observed but with a polyvinyl chloride bag the concentration of cyclosporine was reduced to 94.4% in 24hr. It was found that the factors effecting on the loss of cyclosporine from intravenous solutions were the kind of containers, the length of the administration set, the concentration of cyclosporine injection and the flow rate of solutions.
日本医療薬学会の論文
1988-10-20