9 新型ストレプトスライシン群抗生物貭476-Bの構造
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概要
- 論文の詳細を見る
Two antibiotics 476-A,B were isolated from filtered broth of Streptomyces No.476 strain. The 476-A was identified with emimycin (2-hydroxy pyr-azine 4-oxide). The 476-B was an antibiotic belongs to a basic, water-solble streptothricin group on its physico-chemical properties. Complete hydrolysis of 476-B gave streptolidine (V), N-methyl D-gulosamine (VI), sarcosine (VII), carbon dioxide, ammonia, and miner methylamine, and partial hydrolysis of it gave three inactive compounds of (II), (III) and (IV). A intresting fact was discovered that (II) was regenerated to (I) standing with DCC in pyridinium solution at room temperature for a week. N-guan.-streptolidyl, N-methyl- -D-gulosaminide (IV) was also isolated by D. B. Borders et al. from this group antibiotic LL-AC-541 and decided its structure. On hight resolution MASS spectra, streptolidine moiety and two formulas of C-10 units were decided. Therefore, the structure of new type streptothricin-like 476-B was presumed as (I) by us, and also identified with SF-701.
- 天然有機化合物討論会の論文
- 1970-10-01
著者
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常広
長崎大学薬学部
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北川 常広
長崎大学 薬
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谷山 兵三
長崎大薬学部
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沢田 洋介
長崎大薬学部
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北川 常広
長崎大薬学部
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