Biosynthesis of Streptothricin Antibiotics. VII. Origin of Streptolidine Moiety in Antibiotics from Streptomyces species

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概要

• 論文の詳細を見る

• The effective production of streptothricin antibiotics by the addition of various amino acids (chemistry defined medium C) and the incorporation of ^<14>C-labeled amino acids into streptothricin-C molecule (organic medium E) were studied with a strain of Streptomyces lavendulae OP-2. It was confirmed that proline, alanine, leucine, and arginine stimulated the production of antibiotics, and arginine and glycine promoted the mycelial growth. Of the amino acids tested, arginine was incorporated preferentially into streptothricin-C, but not tartaric acid or streptolidine itself. Approximately a one-half of radioactivity from arginine incorporated into the antibiotic was located in the streptolidine moiety. Furthermore, from the localization of ^<14>C from arginine in the antibiotic molecule from four strains, a different pattern from that described above was observed. Localization of radioactivity in streptolidine moiety of racemomycin-A from S. lavendulae ISP-5069 was lower than that of β-lysine moiety, suggesting that biogenesis of streptolidine in streptothricins from S. lavendulae strains follows two pathways.

• 公益社団法人日本薬学会の論文
• 1978-03-25

著者

• 谷山 兵三

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 沢田 洋介

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 敦賀 真智子

  Department of Microbiology, Osaka College of Pharmacy

• 敦賀 真智子

  Department Of Microbiology Osaka College Of Pharmacy

関連論文

• Chemical Modification of Streptothricin Group Antibiotics. II. Some Amino Derivatives in Racemomycin-A and Their Biological Activity
• Antibiotics Aminosidin. II. Some Amino Derivatives of Aminosidin and Their Biological Activity
• Peptide Mode of β-Lysine Residues in Racemomycin-C
• Studies on the β-Lysine Peptide. II. Synthesis of 〓-(L-β-Lysyl)-L-β-lysine, and Identification with L-β-Lysine Dipeptide Isolated from Racemomycin C Hydrolysate
• Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood
• Physiological Activity of Streptothricin Antibiotics
• ^C-Nuclear Magnetic Resonance Studies on Viomycin and Its Related Compounds
• Insecticidal Activity of Streptothricin Antibiotics
• Toxicological Approaches to Streptothricin Antibiotics. III. Biological Studies on Delayed Toxicity of Streptothricin Antibiotics in Rats
• 67 Streptothricin抗生物質の生合成に関する研究
• 抗生物質Aminosidin(Paromomycin)に関する研究(第3報)アミノ酸誘導体とその生物活性
• Analysis of d-Ethambutol by Circular Dichroism of Its Copper Chelates
• Toxicological Approaches to Streptothricin Antibiotics. II. The Developmental Mechanism of Delayed Toxicity in Mice and Rats
• N-アミノアシルアミノ糖の研究(第1報)N-Lysyl-D-glucosamine関連物質の合成
• Toxicological Approaches to Streptothricin Antibiotics. I. Implications of Delayed Toxicity in Mice
• Biosynthesis of Streptothricin Antibiotics. VII. Origin of Streptolidine Moiety in Antibiotics from Streptomyces species
• Biosynthesis of Streptothricin Antibiotics. VI. Mechanisms of β-Lysine and Its Peptide Formation
• Biosynthesis of Streptothricin Antibiotics. III. Incorporation of D-Glucosamine into D-Gulosamine Moiety of Racemomycin-A
• Studies on the β-Lysine Peptide. IV. Preparation of Semi-synthetic Racemomycins and Their Antimicrobial Activities
• Biosynthesis of Streptothricin Antibiotics. IV. On the Incorporation of L-Arginine into Streptolidine Moiety by Streptomyces lavendulae OP-2
• ストレプトスライシン抗生物質の産生に及ぼすグルコースの阻害効果 : ストレプトスライシン抗生物質S-2産生に関する生化学的研究(第1報)
• Biosynthesis of Streptothricin Antibiotics. II. Catabolite Inhibition of Glucose on Racemomycin-A Production
• Biosynthesis of Streptothricin Antibiotics. I. Incorporation of ^C-Labeled Compound into Racemomycin-A and Distribution of Radioactivity
• Studies on Viomycin. IX. Amino Acid Derivatives of Viomycin
• Streptothricin群抗生物質の化学的修飾に関する研究(第3報)Racemomycin類の部分的N-アセチル化とその生物活性
• Studies on Viomycin. VIII. Selective Modifications of the Terminal Amino Groups of Viomycin
• Studies on Viomycin. VII. Oxidative Modifications of Viomycin
• 33 Viomycinの化学構造と抗菌力発現の関連性について
• The Total Structure of Viomycin by Sequential Analysis
• Characterization of Viomycin and Its Acyl Derivatives
• 34 Viomycinの構造
• 抗生物質 Aminosidin に関する研究(第1報) : Aminosidin I, IIの分離と Paromomycin I, IIとの関係について
• Studies on the β-Lysine Peptide. I. Formation of Copper Complex
• Characterization of Racemomycins
• 9 新型ストレプトスライシン群抗生物貭476-Bの構造
• Streptothricin群抗生物質の化学的修飾に関する研究(第1報) : Citromycin誘導体について(有機化学)
• L-α, β-Diaminopropionic Acidの新合成法
• Streptothricin群抗生物質の化学的修飾に関する研究(第5報)Racemomycin-Aのβ-Lysine部位アミノ酸誘導体とその生物活性
• Streptothricin群抗生物質の化学的修飾に関する研究(第4報)β-N-Acetyl-racemomycin-A誘導体とその抗菌活性
• Studies on the β-Lysine Peptide. III. Synthesis of β-(L-β-Lysyl)-L-β-lysine
• Studies on Chromophore Groups of Streptothricin Group Antibiotics by Optical Rotatory Dispersion and Circular Dichroism

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