Biosynthesis of Streptothricin Antibiotics. II. Catabolite Inhibition of Glucose on Racemomycin-A Production
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概要
- 論文の詳細を見る
The production of the antibiotic, racemomycin-A, was found to be inhibited in the presence of glucose in the medium, although glucose was the best carbon source for Streptomyces lavendulae ISP 5069. The repression by 1% glucose was gradually restorde by the addition of Pharmamedia or amino acid mixture. A severe repression by glucose was also observed at the rapid phase of antibiotic production. On the repression, racemomycin-A produced was incorporated into the mycelium. Xylose and mannitol were weakly repressed on racemomycin-A formation, and maltose caused a mild stimulation of the formation. The production of streptothricin antibiotics in all organisms tested was inhibited by glucose.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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坂本 博
Faculty of Pharmaceutical Sciences, Nagasaki University
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久保 哲蔵
Faculty of Pharmaceutical Sciences, Nagasaki University
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坂本 博
Faculty Of Pharmaceutical Sciences Nagasaki University
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久保 哲蔵
Faculty Of Pharmaceutical Sciences Nagasaki University
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