Biosynthesis of Streptothricin Antibiotics. I. Incorporation of ^<14>C-Labeled Compound into Racemomycin-A and Distribution of Radioactivity
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概要
- 論文の詳細を見る
As a part of the investigation on the biosynthesis of streptothricin antibiotics, the incorporation of ^<14>C-labeled D-glucose, L-lysine, L-arginine, acetic acid, and sodium bicarbonate into racemomycin-A from Streptomyces lavendulae ISP 5069 was examined. By the analysis of the degradation products from ^<14>C-labeled racemomycin-A produced by the addition of lysine, a high rate of the isotope was shown to be present in the β-lysine moiety. Incorporation of glucose followed by degradation of racemomycin-A demonstrated that glucose was incorporated into gulosamine moiety. Acetic acid was incorporated into streptolidine moiety and carbonate showed a preferential incorporation into a carbamoyl group.
- 公益社団法人日本薬学会の論文
- 1976-09-25
著者
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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久保 哲蔵
Faculty of Pharmaceutical Sciences, Nagasaki University
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久保 哲蔵
Faculty Of Pharmaceutical Sciences Nagasaki University
関連論文
- Chemical Modification of Streptothricin Group Antibiotics. II. Some Amino Derivatives in Racemomycin-A and Their Biological Activity
- Antibiotics Aminosidin. II. Some Amino Derivatives of Aminosidin and Their Biological Activity
- Peptide Mode of β-Lysine Residues in Racemomycin-C
- Studies on the β-Lysine Peptide. II. Synthesis of 〓-(L-β-Lysyl)-L-β-lysine, and Identification with L-β-Lysine Dipeptide Isolated from Racemomycin C Hydrolysate
- Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood
- Physiological Activity of Streptothricin Antibiotics
- ^C-Nuclear Magnetic Resonance Studies on Viomycin and Its Related Compounds
- Insecticidal Activity of Streptothricin Antibiotics
- Toxicological Approaches to Streptothricin Antibiotics. III. Biological Studies on Delayed Toxicity of Streptothricin Antibiotics in Rats
- 67 Streptothricin抗生物質の生合成に関する研究
- 抗生物質Aminosidin(Paromomycin)に関する研究(第3報)アミノ酸誘導体とその生物活性
- Analysis of d-Ethambutol by Circular Dichroism of Its Copper Chelates
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- Toxicological Approaches to Streptothricin Antibiotics. I. Implications of Delayed Toxicity in Mice
- Biosynthesis of Streptothricin Antibiotics. VII. Origin of Streptolidine Moiety in Antibiotics from Streptomyces species
- Biosynthesis of Streptothricin Antibiotics. VI. Mechanisms of β-Lysine and Its Peptide Formation
- Biosynthesis of Streptothricin Antibiotics. III. Incorporation of D-Glucosamine into D-Gulosamine Moiety of Racemomycin-A
- Studies on the β-Lysine Peptide. IV. Preparation of Semi-synthetic Racemomycins and Their Antimicrobial Activities
- Biosynthesis of Streptothricin Antibiotics. IV. On the Incorporation of L-Arginine into Streptolidine Moiety by Streptomyces lavendulae OP-2
- ストレプトスライシン抗生物質の産生に及ぼすグルコースの阻害効果 : ストレプトスライシン抗生物質S-2産生に関する生化学的研究(第1報)
- Biosynthesis of Streptothricin Antibiotics. II. Catabolite Inhibition of Glucose on Racemomycin-A Production
- Biosynthesis of Streptothricin Antibiotics. I. Incorporation of ^C-Labeled Compound into Racemomycin-A and Distribution of Radioactivity
- Studies on Viomycin. IX. Amino Acid Derivatives of Viomycin
- Streptothricin群抗生物質の化学的修飾に関する研究(第3報)Racemomycin類の部分的N-アセチル化とその生物活性
- Studies on Viomycin. VIII. Selective Modifications of the Terminal Amino Groups of Viomycin
- Studies on Viomycin. VII. Oxidative Modifications of Viomycin
- 33 Viomycinの化学構造と抗菌力発現の関連性について
- The Total Structure of Viomycin by Sequential Analysis
- Characterization of Viomycin and Its Acyl Derivatives
- 34 Viomycinの構造
- 抗生物質 Aminosidin に関する研究(第1報) : Aminosidin I, IIの分離と Paromomycin I, IIとの関係について
- Studies on the β-Lysine Peptide. I. Formation of Copper Complex
- Characterization of Racemomycins
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- Streptothricin群抗生物質の化学的修飾に関する研究(第1報) : Citromycin誘導体について(有機化学)
- L-α, β-Diaminopropionic Acidの新合成法
- Streptothricin群抗生物質の化学的修飾に関する研究(第5報)Racemomycin-Aのβ-Lysine部位アミノ酸誘導体とその生物活性
- Streptothricin群抗生物質の化学的修飾に関する研究(第4報)β-N-Acetyl-racemomycin-A誘導体とその抗菌活性
- Studies on the β-Lysine Peptide. III. Synthesis of β-(L-β-Lysyl)-L-β-lysine
- Studies on Chromophore Groups of Streptothricin Group Antibiotics by Optical Rotatory Dispersion and Circular Dichroism