Toxicological Approaches to Streptothricin Antibiotics. II. The Developmental Mechanism of Delayed Toxicity in Mice and Rats
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概要
- 論文の詳細を見る
In order to investigate the mode of the delayed toxicity of streptothricin antibiotics, ^<14>C-glycyl-racemomycin-A and racemomycin-D were each administered intravenously to mice and rats in a seuviving dose. As to the distribution of ^<14>C-glycyl-racemomycin-A in the organs of mice, studies confirmed us that it was distributed in kidney in a high concentration in comparison with the distribution in the other organs. Therefore, pathohistological reviews were carried out on the kidney which was whitened macroscopically. As a result, severe toxicity wide-spread in the cortex renis was observed in the kidney. From these results, it was recogenized that streptothricin antibiotics produce nephrotoxicity. As to the developmental mechanism of the delayed toxicity, the authors presented the assumption that after the administered antibiotic us, in vivo, transformed into acid, lactam ring of which is broken from examination of radiochromatogram of metabolite in urine, and that the acute toxicity of that acid is responsible for the delayed toxicity.
- 公益社団法人日本薬学会の論文
- 1979-01-25
著者
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森本 一洋
大阪薬科大学第2薬剤学教室
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森本 一洋
大阪薬科大学 薬剤学教室
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松田 弘幸
Research Laboratories Rohoto Pharmaceutical Co. Ltd.
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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森坂 勝昭
Osaka University of Pharmaceutical Sciences
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斎藤 元一
Osaka College of Pharmacy
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