Streptothricin群抗生物質の化学的修飾に関する研究(第5報)Racemomycin-Aのβ-Lysine部位アミノ酸誘導体とその生物活性

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概要

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• Amino acid derivatives of Racemomycin-A, one of streptothricin group antibiotics, were prepared. Eleven kinds of amino acid were introduced into the amino group in ε-position of the β-lysine moiety of Racemomycin-A by the active esteriftcation method. All the derivatives prepared had an antibacterial activity but less than that of the original antibiotic. Acute toxicity of the derivatives with neutral and acidic amino acid was less than that of the original antibiotic and that of the basic amino derivatives was much lower than that of Racemomycin-C. In all the derivatives, however, prolonged toxicity remained.

• 公益社団法人日本薬学会の論文
• 1974-07-25

著者

• 谷山 兵三

  長崎大学薬学部

• 谷山 兵三

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 沢田 洋介

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 沢田 洋介

  長崎大学薬学部

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