Biosynthesis of Streptothricin Antibiotics. VI. Mechanisms of β-Lysine and Its Peptide Formation
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概要
- 論文の詳細を見る
1. Streptomyces lavendulae ISP-5069 produces racemomycin-A which yields β-lysine as a component on hydrolysis. β-Lysine was derived from an intermediate α, ε-diaminopimelic acid via lysine pathway. Exogenous lysine acted as a donor of β-lysine to form racemomycin-C and-B by S. lavendulae NT-1008 by means of incorporation of ^<14>C-labeled lysine. 2. Two taxonomically different strains, S. lavendulae NT-1008 and S. albidoflavus S-0003,were selected as the strains producing racemomycin-A, -C, and-B as a mixture. These antibiotics were present both in the intracellular pool and in the broth. 3. Addition of ^<14>C-racemomycin-A to the culture medium resulted in the incorporation of ^<14>C into racemomycin-C and-B. Majority of the radioactivity was present in the extracellular racemomycin-C and-B, but a significant portion was present in the intracellular antibiotics. These data indicate that racemomycin-C and-B were transformed stepwisely from racemomycin-A and β-lysine, suggesting an endogenous formation.
- 公益社団法人日本薬学会の論文
- 1977-12-25
著者
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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中野 史朗
Faculty of Pharmaceutical Sciences, Nagasaki University
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中野 史朗
Faculty Of Pharmaceutical Sciences Nagasaki University
関連論文
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- Peptide Mode of β-Lysine Residues in Racemomycin-C
- Studies on the β-Lysine Peptide. II. Synthesis of 〓-(L-β-Lysyl)-L-β-lysine, and Identification with L-β-Lysine Dipeptide Isolated from Racemomycin C Hydrolysate
- Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood
- Physiological Activity of Streptothricin Antibiotics
- ^C-Nuclear Magnetic Resonance Studies on Viomycin and Its Related Compounds
- Insecticidal Activity of Streptothricin Antibiotics
- Toxicological Approaches to Streptothricin Antibiotics. III. Biological Studies on Delayed Toxicity of Streptothricin Antibiotics in Rats
- 67 Streptothricin抗生物質の生合成に関する研究
- 抗生物質Aminosidin(Paromomycin)に関する研究(第3報)アミノ酸誘導体とその生物活性
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- Biosynthesis of Streptothricin Antibiotics. VII. Origin of Streptolidine Moiety in Antibiotics from Streptomyces species
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- Biosynthesis of Streptothricin Antibiotics. III. Incorporation of D-Glucosamine into D-Gulosamine Moiety of Racemomycin-A
- Studies on the β-Lysine Peptide. IV. Preparation of Semi-synthetic Racemomycins and Their Antimicrobial Activities
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- ストレプトスライシン抗生物質の産生に及ぼすグルコースの阻害効果 : ストレプトスライシン抗生物質S-2産生に関する生化学的研究(第1報)
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- Studies on Viomycin. IX. Amino Acid Derivatives of Viomycin
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- Studies on the β-Lysine Peptide. I. Formation of Copper Complex
- Characterization of Racemomycins
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- L-α, β-Diaminopropionic Acidの新合成法
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- Studies on the β-Lysine Peptide. III. Synthesis of β-(L-β-Lysyl)-L-β-lysine
- Studies on Chromophore Groups of Streptothricin Group Antibiotics by Optical Rotatory Dispersion and Circular Dichroism