The Total Structure of Viomycin by Sequential Analysis
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概要
- 論文の詳細を見る
The novel partial hydrolysis of peptide bonds by using N→O acyl migrative reactions followed by the methanolysis of the resulting ester linkages were studied to give the successful application with tetrahydro derivative of viomycin, a tuberculostatic antibiotic. Also, the partial hydrolysis of perhydroacetylviomycin yielded two peptide fragments. The sequential analysis of these fragments by Edman-dansyl procedures and the end group analysis concluded that the primary structure of viomycin is formulated as XXV. The sequence is well compatible to the chemical formula I, the one of recently proposed two structures.
- 公益社団法人日本薬学会の論文
- 1972-10-25
著者
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常廣
Faculty of Pharmaceutical Sciences, Nagasaki University
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藤原 邦雄
Faculty of Pharmaceutical Sciences, Nagasaki University
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三浦 孝子
Faculty of Pharmaceutical Sciences, Nagasaki University
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藤原 邦雄
長崎大学薬学部
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三浦 孝子
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常廣
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常廣
Faculty Of Pharmaceutical Sciences
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