Streptothricin群抗生物質の化学的修飾に関する研究(第1報) : Citromycin誘導体について(有機化学)
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概要
- 論文の詳細を見る
Citromycin (I) is converted into inactive citromycinic acid (II) by treatment with 3N hydrochloric acid and toxicity of II was less than one-half of that of I. Deformiminocitromycin (III) obtained by treatment with methanolic ammonia and deformiminocitromycin N-acetate (V) obtained by treatment with N-acetoxysuccinimide no longer had the original antibacterial activity. These facts indicate that antibacterial activity of citromycin requires the partial structure of (i) formation of a lactam ring in the streptolidine moiety and (ii) protection of the terminal amino group in glycine by a basic group like formimino, and that deformimination and N-acetylation results in the loss of its antibacterial activity.
- 公益社団法人日本薬学会の論文
- 1972-02-25
著者
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谷山 兵三
長崎大学薬学部
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
長崎大学薬学部
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橋本 敬三
長崎大学薬学部
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