Analysis of d-Ethambutol by Circular Dichroism of Its Copper Chelates
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概要
- 論文の詳細を見る
Antituberculostatic agent ethambutol, possessing a little molar specific rotation, was converted to several metal chelated derivatives. Among them, the copper chelate showed a large ellipticity value in its circular dichroism (CD) spectrum. A quantitative analysis of ethambutol by means of the copper chelation followed by CD spectroscopic measurements were investigated. Thus, addition of 0.1 ml of 0.3% ethanolic solution of ethambutol to 2.9 ml of 0.01% ethanolic solution of cupric chloride was ready to form copper chelated ethambutol which gave CD ellipticity value 4.6±0.3 in its CD spectrum. The present method is one of the convenient procedures to introduce a chromophoric nature to an optically active amino alcohol for a CD measurement.
- 公益社団法人日本薬学会の論文
- 1976-12-25
著者
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尾家 重治
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常廣
長崎大学薬学部
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常廣
Faculty of Pharmaceutical Sciences, Nagasaki University
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北川 常広
長崎大学薬学部
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北川 常廣
Faculty Of Pharmaceutical Sciences Nagasaki University
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北川 常広
長崎大学 薬
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北川 常廣
Faculty Of Pharmaceutical Sciences
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