33 Viomycinの化学構造と抗菌力発現の関連性について

概要

論文の詳細を見る
In the course of investigations on structure-activity relationships of viomycin(VM), a tuberculoststic antibiotic, chemical modifications of its reactive functional groups tuberactidine residue and its chromophoric 3-ureidodehydroalanine residue were studied. Thus, alkali treatment or reaction with bromine resulted abnormal reaction products AnVM or BroxoVM respectively those of which were characterised by chemical and physical analysis. Antimicrobial activities of oxidations products of VM showed nullified potencies, the results of which were agreeable from the predictions that D-form or dehydro derivative of amino acid residue are important factor for their potencies of original antibiotics while, 4HVM, a hydrogenated product of the chromophore group to alanine moiety still possessed one forth of original potencies. Chemical modifications on hydroxyl function of tuberactidine residue did not resulted significant inactivations except AnVM. The reason for the inactivation of AnVM could be attributed for conformational changes of 16 membered cyclic peptide ring.
天然有機化合物討論会の論文
1973-10-01