Streptothricin群抗生物質の化学的修飾に関する研究(第3報)Racemomycin類の部分的N-アセチル化とその生物活性

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概要

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• Racemonycin-A and -C were respectively acetylated with N-acetoxysuccinimide. The structures of these derivatives were determined by dinitrophenyl derivative method. N-Acetyl-racemomycin-A exhibited a weak antimicrobial activity and the original toxicity was decreased. N-Acetyl-racemomycin-C also had lower antimicrobial activity than the original antibiotic. These results showed that ε- and ε'-amino groups of β-lysine residue in these antibiotics are an important site for appearance of their biological activity.

• 公益社団法人日本薬学会の論文
• 1974-02-25

著者

• 谷山 兵三

  長崎大学薬学部

• 谷山 兵三

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 沢田 洋介

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 沢田 洋介

  長崎大学薬学部

• 坂本 博

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 坂本 博

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 坂本 博

  長崎大学薬学部

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