Antibiotics Aminosidin. II. Some Amino Derivatives of Aminosidin and Their Biological Activity
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概要
- 論文の詳細を見る
Three penta-N-phenylalkylideneaminosidins, two penta-N-phenylalkylaminosidins, and two N-methylaminosidins were prepared, and their antimicrobial activities in vitro were determined. Penta-N-phenylalkylideneaminosidins had antimicrobial activity approximately equal to or slightly less than that of aminosidin. However, penta-N-phenylalkylaminosidins and N-methylaminosidins were devoid of antimicrobial activity. Penta-N-benzylideneaminosidin protected mice from death by Staphylococcus aureus and Escherichia coli infections, and acute toxicity of the penta-N-benzylideneaminosidin was less than that of aminosidin by a subcutaneous route.
- 社団法人日本薬学会の論文
- 1973-03-25
著者
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田中 重雄
Faculty Of Pharmaceutical Sciences Nagasaki University
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
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