Studies on Viomycin. VIII. Selective Modifications of the Terminal Amino Groups of Viomycin

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概要

• 論文の詳細を見る

• In order to determine which amino function of N-terminal two amino groups is important factor for the exhibition of antimicrobial activity of viomycin, selective acetylations for both amino functions were performed. The limited acetylation gave III exclusively while, the limited benzyloxycarbonylation followed by acetylation and debenzyloxycarbonylation yielded VI. Antimicrobial activities of III and VI showed almost the same reduced activities than I but somewhat stronger activities than II. From these results both of the terminal amino functions are deduced to be important factors for the exhibition of the activities of I.

• 公益社団法人日本薬学会の論文
• 1975-09-25

著者

• 北川 常廣

  長崎大学薬学部

• 谷山 兵三

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 北川 常廣

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 三浦 孝子

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 三浦 孝子

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 北川 常広

  長崎大学薬学部

• 北川 常廣

  Faculty Of Pharmaceutical Sciences Nagasaki University

• 北川 常広

  長崎大学 薬

• 高石 美佐子

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 北川 常廣

  Faculty Of Pharmaceutical Sciences

• 高石 美佐子

  Faculty Of Pharmaceutical Sciences Nagasaki University

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