Chemical Modification of Streptothricin Group Antibiotics. II. Some Amino Derivatives in Racemomycin-A and Their Biological Activity
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概要
- 論文の詳細を見る
Racemomycin-A, one of streptothricin-group antibiotics, was condensed with aromatic aldehydes. These N-phenylalkylidene derivatives were active against gram-positive and-negative bacteria and Mycobacterium, and showed a tendency of lower delayed toxicity in mice. N-Phenylalkyl and N-acetyl derivatives of Racemomycin-A showed poor antimicrobial activity but with weaken delayed toxicity.
- 社団法人日本薬学会の論文
- 1974-02-25
著者
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田中 重雄
Faculty Of Pharmaceutical Sciences Nagasaki University
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谷山 兵三
Faculty Of Pharmaceutical Sciences Nagasaki University
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沢田 洋介
Faculty Of Pharmaceutical Sciences Nagasaki University
関連論文
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- Peptide Mode of β-Lysine Residues in Racemomycin-C
- Studies on the β-Lysine Peptide. II. Synthesis of 〓-(L-β-Lysyl)-L-β-lysine, and Identification with L-β-Lysine Dipeptide Isolated from Racemomycin C Hydrolysate
- Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood
- Physiological Activity of Streptothricin Antibiotics
- ^C-Nuclear Magnetic Resonance Studies on Viomycin and Its Related Compounds
- Insecticidal Activity of Streptothricin Antibiotics
- Toxicological Approaches to Streptothricin Antibiotics. III. Biological Studies on Delayed Toxicity of Streptothricin Antibiotics in Rats
- 67 Streptothricin抗生物質の生合成に関する研究
- 抗生物質Aminosidin(Paromomycin)に関する研究(第3報)アミノ酸誘導体とその生物活性
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- Biosynthesis of Streptothricin Antibiotics. VII. Origin of Streptolidine Moiety in Antibiotics from Streptomyces species
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- Biosynthesis of Streptothricin Antibiotics. III. Incorporation of D-Glucosamine into D-Gulosamine Moiety of Racemomycin-A
- Studies on the β-Lysine Peptide. IV. Preparation of Semi-synthetic Racemomycins and Their Antimicrobial Activities
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- ストレプトスライシン抗生物質の産生に及ぼすグルコースの阻害効果 : ストレプトスライシン抗生物質S-2産生に関する生化学的研究(第1報)
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- Biosynthesis of Streptothricin Antibiotics. I. Incorporation of ^C-Labeled Compound into Racemomycin-A and Distribution of Radioactivity
- Studies on Viomycin. IX. Amino Acid Derivatives of Viomycin
- Streptothricin群抗生物質の化学的修飾に関する研究(第3報)Racemomycin類の部分的N-アセチル化とその生物活性
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- 33 Viomycinの化学構造と抗菌力発現の関連性について
- The Total Structure of Viomycin by Sequential Analysis
- Characterization of Viomycin and Its Acyl Derivatives
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- Studies on the β-Lysine Peptide. I. Formation of Copper Complex
- Characterization of Racemomycins
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- L-α, β-Diaminopropionic Acidの新合成法
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- Streptothricin群抗生物質の化学的修飾に関する研究(第4報)β-N-Acetyl-racemomycin-A誘導体とその抗菌活性
- Studies on the β-Lysine Peptide. III. Synthesis of β-(L-β-Lysyl)-L-β-lysine
- Studies on Chromophore Groups of Streptothricin Group Antibiotics by Optical Rotatory Dispersion and Circular Dichroism