Nasal Absorption of Nifedipine from Gel Preparations in Rats(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
Nasal absorption of nifedipine from polyethylene glycol(PEG) 400, aqueous Carbopol gel and Carbopol-PEG gel was investigated with the aim of obtaining high bioavailability and prolonged action. Nasal administration of nifedipine in PEG resulted in rapid absorption and high maximum concentration(C_<max>). However, the elimination of nifedipine from plasma was very rapid. Nifedipine plasma concentration after nasal administration of nifedipine in aqueous Carbopol gel was very low. On the other hand, Carbopol-PEG gel(containing 50% w/v PEG) showed a relatively high nifedipine concentration and a prolonged action.
- 公益社団法人日本薬学会の論文
- 1987-07-25
著者
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森本 一洋
大阪薬科大学第2薬剤学教室
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森本 一洋
大阪薬科大学 薬剤学教室
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森坂 勝昭
Osaka University of Pharmaceutical Sciences
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森本 一洋
Department of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences
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森坂 勝昭
Department of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences
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田畑 博文
Department of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences
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田畑 博文
Department Of Pharmaceutical Sciences Osaka University Of Pharmaceutical Sciences
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