Structure Activity Relationship of Inhibitors Specific for Prolyl Endopeptidase(Biological Chemistry)

スポンサーリンク

概要

• 論文の詳細を見る

• Structural requirements of N-blocked L-proline derivatives as specific inhibitors for prolyl endopeptidase were investigated using a series of substrate analogs. Replacement of L-proline by its D-isomer remarkably reduced the inhibition. Introduction of a sulfur atom in proline and/or in the penultimate pyrrolidine rings significantly increased the inhibition, but the introduction of oxygen rather diminished the activity. A peptide linkage (acid-amide bond) between the proline and the pyrrolidine ring was also required to keep the inhibitory activity. A benzyloxycarbonyl group was most effective as an N-blocked component of the inhibitors.

• 社団法人日本農芸化学会の論文
• 1991-01-23

著者

• YAMAMOTO Naoko

  School of Humanities and Social Sciences at Osaka Prefecture University

• YOSHIMOTO TADASHI

  School of Pharmaceutical Sciences, Nagasaki University

• TSURU DAISUKE

  School of Pharmaceutical Sciences, Nagasaki University

• Yoshimoto T

  Nagasaki Univ. Nagasaki Jpn

• Yoshlmoto Tadashi

  School Of Pharmaceutical Sciences Nagasaki University

• Yoshimoto Tadashi

  School Of Pharmaceutical Sciences Nagasaki University

• Yoshimoto Tadashi

  School Of Pharmaceutical Sciences Nagasaki University:yakult Central Institute For Microbiological R

• Yoshimoto Tadashi

  School Of Pharmaceutical Sciences Nagasiki University

• FURUKAWA Sunao

  School of Pharmaceutical Sciences, Nagasaki University

• IKEZAWA Ryuhei

  School of Pharmaceutical Sciences, Nagasaki University

• Tsuru D

  School Of Pharmaceutical Sciences Nagasaki University:yakult Central Institute For Microbiological R

• Tsuru Daisuke

  Department Of Applied Microbial Technology Sojo University

• Yamamoto Naoko

  School Of Pharmaceutical Sciences Nagasaki University

• Tsuru D

  Department Of Applied Microbial Technology Sojo University

• Ikezawa Ryuhei

  School Of Pharmaceutical Sciences Nagasaki University

• Furukawa Sunao

  School Of Pharmaceutical Sciences Nagasaki University

• Tsuru Daisuke

  School Of Pharmaceutical Sciences Nagasaki University

• Yoshimoto Tadashi

  School of Pharamaceutical Sciences, Nagasaki University

関連論文

• 2A16-4 epsilon-Poly-L-lysine(PL)分解酵素遺伝子の取得と破壊株を用いた機能解析(遺伝子工学・核酸工学,一般講演)
• 3P-1072 エナンチオ選択的イミン還元酵素の探索と特徴解析(2a酵素学,酵素工学,一般講演,酵素学,タンパク質工学および酵素工学,伝統の技と先端科学技術の融合)
• Prolidase from Xanthomonas maltophilia : Purification and Characterization of the Enzyme
• Age Effects on Bilingual Stroop Interference : A Test to Demystify Competing Hypotheses-The Inhibitory Mechanism and The Reserve Hypothesis
• Nucleotide Sequence of the Neutral Protease Gene from Bacillus subtilis var. amylosacchariticus
• Glutathione-independent Formaldehyde Dehydrogenase from Pseudomons putida : Survey of Functional Groups with Special Regard for Cysteine Residues
• Prolylcarboxypeptidase (Angiotensinase C) : Purification and Characterization of the Enzyme from Xanthomonas maltophilia
• Degradation of Streptomyces Metalloprotease Inhibitor (SMPI) by Neutral Protease from Bacillus subtilis var. amylosacchariticus
• CPT-11 Converting Enzyme from Rat Serum : Purification and Some Properties
• NOVEL AND POTENT INHIBITORS SPECIFIC FOR PROLYL ENDOPEPTIDASE AND THEIR ANTI-AMNESIC EFFECT
• SPECIFIC INHIBITORS FOR PROLYL ENDOPEPTIDASE AND THEIR ANTI-AMNESIC EFFECT
• Specific Inhibition of Dipeptidyl Aminopeptidase IV by a New Synthetic Inhibitor, L-Thioprolylthiazolidine(Biological Chemistry)
• Structure Activity Relationship of Inhibitors Specific for Prolyl Endopeptidase(Biological Chemistry)
• Purification and Characterization of Proline Iminopeptidase from Lyophyllum cinerascens
• 516 Studies on Prolyl Endopeptidase from Shakashimeji (Lyophyllum Cinerascens) : Purification and Enzymatic Properties.
• Effects of an 'enrichment feeder' on behavior and feather conditions of caged laying hens
• 2Fp04 シアノヒドリンに作用するニトリラーゼの特性(酵素学,酵素工学,タンパク質工学,一般講演)
• 2Fp03 微生物による1,3-アダマンタンジオールの位置選択的水酸化(酵素学,酵素工学,タンパク質工学,一般講演)
• 2Fp05 Fusarium属カビのニトリラーゼの分子特性の解析(酵素学,酵素工学,タンパク質工学,一般講演)
• 1Fp09 4-ヒドロキシ安息香酸脱炭酸酵素の構造と機能発現の相関(酵素学,酵素工学,タンパク質工学,一般講演)
• 2B15-2 マンデロニトリルに作用する立体選択的ニトリラーゼ(酵素学・酵素工学・タンパク質工学,一般講演)
• 1F15-2 イソオイゲノール分解酵素の遺伝子クローニングと一次構造解析(酵素学,酵素工学,タンパク質工学,一般講演)
• 1F15-3 二相系におけるイソオイゲノールのバニリンへの微生物変換(酵素学,酵素工学,タンパク質工学,一般講演)
• 可逆的脱炭酸酵素の特性解析と芳香族カルボン酸の合成について
• ACTIVE SITE STRUCTURE AND FUNCTION OF NEUTRAL PROTEASE FROM BACILLUS SUBTILIS var. AMYLOSACCHARITICUS
• Chemical Modification of Neutral Protease from Bacillus subtilis var. amylosacchariticus : Assignment of Tyrosyl Residues Iodinated(Biological Chemistry)
• Dye-sensitized Photooxidation of Neutral Protease from Bacillus subtilis var. amylosacchariticus : Assignment of Histidine Residue Oxidized(Biological Chemistry)
• Nucleotide Sequence of the Gene Encoding Pepstatin-insensitive Acid Protease B, Scytalidopepsin B, of Scytalidium lignicolum
• Expression and Secretion of Scytalidopepsin B, an Acid Protease from Scytalidium lignicolum, in Yeast
• Nucleotide Sequence of the Gene Encoding the Precursor Protein of Pepstatin insensitive Acid Protease B, Scytalidopepsin B, from Scytalidium lignicolum
• Purification and Characterization of a Prolyl Endopeptidase from Pseudomonas sp. KU-22
• Substrate Recognition Mechanism of Proly Aminopeptidase from Serratia marcescens^1
• Glutamate 83 Is Important for Stabilization of Domain-Domain Conformation of Thermus aquaticus Glycerol Kinase
• Crystal Structure of Prolyl Aminopeptidase from Serratia marcescens
• Cloning, Sequencing, High Expression, and Crystallization of the Thermophile Thermus aquaticus Glycerol Kinase
• Roles of the Ser146, Tyr159, and Lys163 Residues in the Catalytic Action of 7α-Hydroxysteroid Dehydrogenase from Escherichia coli
• Cloning and Expression of the cDNA Encoding Prolyl Oligopeptidase (Prolyl Endopeptidase) from Bovine Brain
• Prolyl Aminopeptidase from Serratia marcescens: Cloning of the Enzyme Gene and Crystalliztion of the Expressed Enzyme^1
• Purification and Characterization of Thermostable Glycerol Kinase from Thermus flavus
• Dipeptidyl Peptidase IV from Xanthomonas maltophilia: Sequencing and Expression of the Enzyme Gene and Charactrization of the Expressed Enzyme
• Prolyl Aminopeptidase Is Also Present in Enterobacteriaceae: Cloning and Sequencing of the Hafnia alvei Enzyme-Gene and Characterization of the Expressed Enzyme
• Protease II from Moraxella lacunata: Cloning, Sequencing, and Expression of the Enzyme Gene, and Crystallization of the Expressed Enzyme
• Partial Purification and Characterization of Two β-Glucuronidases from Alcaligenes NG-11(Biological Chemistry)
• Novel Aminopeptidase Specific for Glycine from Actinomucor elegans(Biochemistry & Molecular Biology)
• Prolyl Endopeptidase Inhibitors Derived from Actinomycetes
• Secretion of Escherichia coli Aminopeptidase P in Bacillus subtilis Using the Prepro-Structure Coding Region of Subtilisin Amylosacchariticus
• Novel Prolyl Tri/Tetra-Peptidyl Aminopeptidase from Streptomyces mobaraensis : Substrate Specificity and Enzyme Gene Cloning
• CLONING OF AMINOPEPTIDASES P AND N GENES AND CHARACTERIZATION OF EXPRESSED ENZYMES
• Inactivation of Scytatidium lignicolum Acid Protease B with 1,2-Epoxy-3-(4'-azido-2'-nitrophenoxy)propanet(Biological Chemistry)
• Complete Amino Acid Sequence of Neutral Protease from Bacillus subtilis var. amylosacchariticus(Biological Chemistry)
• Inhibition of Scytalidium lignicolum Acid Protease B by 1-Diazo-3-phenyl-2-propanone(Biological Chemistry)
• Directed Evolution to Improve the Thermostability of Prolyl Endopeptidase^1
• Purification and Some Properties of the Enzyme Catalyzing the C_γ-Elimination of a Diarylpropane-type Lignin Model from Pseudomonas paucimobilis TMY1009(Biological Chemistry)
• Purification and Some Properties of Lignostilbene-α,β-dioxygenase Responsible for the C_α-C_β Cleavage of a Diarylpropane Type Lignin Model Compound from Pseudomonas sp. TMY1009(Biological Chemistry)
• A Novel Assay Method for Aminopeptidase P and Partial Purification of Two Types of the Enzyme in Escherichia coli(Biological Chemistry)
• An Aminopeptidase N from Escherichia coli HB101: Purification and Demonstration that the Enzyme Possesses Arylamidase and Peptidase Activitiest(Biological Chemistry)
• 406 Comparison of Prolyl Endopeptidases Produced in Culture Medium and Fruit-body of Agaricus bisporus (Mushroom)
• 有機溶媒耐性酵素を活用したケミカル生産(疎水性ケミカルのバイオプロダクションを目指した基盤研究)
• Behavioral Responses of Japanese Wild Boars to the Person in Attendance during the Pre- and Post-farrowing Periods under Captive Conditions
• Behavioral Responses of Japanese Wild Boars to the Person in Attendance during the Pre- and Post-farrowing Periods under Captive Conditions
• Color Discrimination in Dogs
• Color Discrimination in Dogs
• Behavior of Japanese Wild Boars, Sus Scrofa leucomystax, during the First Week after Parturition in Farrowing Pens
• Behavior of Japanese Wild Boars, Sus Scrofa leucomystax, during the First Week after Parturition in Farrowing Pens
• Courtship Behavior of Japanese Wild Boars, Sus scrofa leucomystax, under Captive Conditions
• Courtship Behavior of Japanese Wild Boars, Sus scrofa leucomystax, under Captive Conditions
• Preparation of Axially Chiral Biphenyl Diphosphine Ligands and Their Application in Asymmetric Hydrogenation
• Formaldehyde Dehydrogenase from Pseudomonas putida: The Role of A Cysteinyl Residue in the Enzyme Activity(Biological Chemistry)
• FORMALDEHYDE DEHYDROGENASE FROM PSEUDOMONAS PUTIDA : CHARACTERIZATION AS A ZINC METALLOENZYME AND THE REACTION MECHANISM
• Purification and Enzymatic Properties of an Endo-α-N-Acetyl-Galactosaminidase from Bacillus laterosporus SS-16
• Are Litter Mates Needed for Each Piglet to Keep its Exclusive Teat after the Establishment of a Teat Order?
• 2Da05 アミノ基転移酵素による光学活性アミンの合成(酵素学・酵素工学,一般講演)
• 微生物の有機溶媒耐性酵素とそのケミカル生産への活用
• Cloning of L-Amino Acid Deaminase Gene from Proteus vulgaris
• 2Da04 酢酸菌による1,3-プロパンジオール類からアクリル酸類への変換(酵素学・酵素工学,一般講演)
• Membrane Topology and Functional Analysis of Methylobacillus sp. 12S Genes epsF and epsG, Encoding Polysaccharide Chain-Length Determining Proteins
• 2Cp23 Rhodococcus rhodochrous J1ニトリラーゼによるマロノニトリル誘導体の立体選択的加水分解(酵素学,酵素工学,一般講演)
• 2Cp22 (S)-イミン還元酵素による光学活性アミン合成(酵素学,酵素工学,一般講演)
• Courtship Behavior of Japanese Wild Boars, Sus scrofa leucomystax, under Captive Conditions
• Color Discrimination in Dogs
• 2P-042 様々なイミンに作用する(R)-イミン還元酵素の特徴解析(酵素学,酵素工学,一般講演)
• 2P-041 1-アセチル-2-メチルピロリジンを立体選択的に加水分解するハイドロラーゼの特徴解析(酵素学,酵素工学,一般講演)
• 2P-039 1,4-ジアセチル-2-メチルピペラジンに作用する立体特異的ハイドロラーゼの探索(酵素学,酵素工学,一般講演)
• Roles of the Ser146, Tyr159, and Lys163 Residues in the Catalytic Action of 7.ALPHA.-Hydroxysteroid Dehydrogenase from Escherichia coli.
• Prolyl Aminopeptidase Is Also Present in Enterobacteriaceae: Cloning and Sequencing of the Hafnia alvei Enzyme-Gene and Characterization of the Expressed Enzyme.
• Substrate Recognition Mechanism of Prolyl Aminopeptidase from Serratia marcescens.
• Crystal Structure of Prolyl Aminopeptidase from Serratia marcescens.
• Prolyl Aminopeptidase from Serratia marcescens: Cloning of the Enzyme Gene and Crystallization of the Expressed Enzyme.
• Novel Prolyl Tri/Tetra-Peptidyl Aminopeptidase from Streptomyces mobaraensis: Substrate Specificity and Enzyme Gene Cloning

もっと見る 閉じる

スポンサーリンク