Role of Methylcitric Acid Cycle in Catabolism of Amino Acids by Saccharomycopsis lipolytica(Microbiology & Fermentation Industry)
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概要
- 論文の詳細を見る
We examined the production of 2-methylisocitric acid, an intermediate of the constitutive methylcitric acid cycle involved in propionyl-CoA oxidation during the catabolism of different amino acids by a mutant lacking 2-methylisocitrate lyase, a key enzyme of the cycle. The acid was produced equimolarly from isoleucine within a range of amounts of the amino acid added. The amount of the acid produced also increased depending upon the amounts of valine, threonine, methionine, homoserine, and α-aminobutyric acid. However, only a little acid was produced from the 13 other amino acids tested. These results indicated that propionyl-CoA was involved in the catabolism of the first six amino acids named, but not in the other 13. Intracellular amino acids were therefore part of metabolic turnover and the constitutive cycle functioned in the catabolism of propionyl-CoA derived from the turnover.
- 社団法人日本農芸化学会の論文
- 1987-04-23
著者
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Uchiyama Hiroo
National Institute For Environmental Studies
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Tabuchi T
Institute Of Bioscience And Biotechnology Aomori University
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Tabuchi Takeshi
Institute Of Applied Biochemistry The University Of Tsukuba
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MIYAKOSHI Shunichi
Institute of Applied Biochemistry, University of Tsukuba
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ENAMI Kengo
Institute of Applied Biochemistry, University of Tsukuba
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Miyakoshi S
Gunma National College Of Technology
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Enami Kengo
Institute Of Applied Biochemistry University Of Tsukuba
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Miyakoshi Shunichi
Institute Of Applied Biochemistry University Of Tsukuba
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