Expression of Adhesion Molecules in the Lymphoid Cell Distribution in Rheumatoid Synovial Membrane

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To investigate the mechanism of cellular infiltrates in the lining layer and Jymphocytic infiltrates of the rheumatoid synovial membrane, immunohistocherhical and immunoelectron microscopic studies utilizing monoclonal antibodies against the adhesion molecules, CD54 (ICAM-1), GD11a (LFA-1), and CDw49e (VLA-5) were carried out to determine the pattern of distribution of these molecules in the rheumatoid synovial membrane. Treatment with anti-ICAM-1 resulted in membrane staining of most of the lining cells, suggesting the possibility that ICAM-1 may function to facilitate the adhesion of ICAM-1 bearing type A cells to type B cells of the lining layer. ICAM-1 positive macrophages and fibroblasts were often in contact with lymphoid cells suggesting that cellular immune reaction occurs in the transitional area, and also that the lining cells may utilize VLA-5 for anchorage to fibronectin at the surface of the synovial membrane. ICAM-1 staining was weak in lymphoid aggregates, but strong in the transitional area, indicating a paucity of ICAM-1 bearing cells in the lymphocyte rich areas. On the other hand, LFA-1 staining was very strong in the lymphoid aggregates and only moderate in transitional areas. This suggests that the large numbers of T4 cells present in the lymphocyte rich areas are sufficiently activated to express substantial levels of LFA-1, and also that the LFA-1 molecule is an important receptor for emigration from postcapillary venules. The VLA-5 molecules stained in the transitional areas may provide appropriate adhesion and anchorage for the achievement of the variety of immune reactions which occur in these areas.
神戸大学の論文
1997-01-24

Expression of Adhesion Molecules in the Lymphoid Cell Distribution in Rheumatoid Synovial Membrane

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