β1-Integrin Expression in the Rheumatoid Synovial-Pannus Formation

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In order to investigate the mechanism of synovial pannus formation in rheumatoid arthritis, using an immunohistochemical staining technique with monoclonal antibodies against adhesion molecules, anti-CDw49a (VLA-1), CDw49b (VLA-2), CDw49c (VLA-3), CDw49d (VLA-4) and CDw49e (VLA-5), the pattern of distribution of these molecules at the rheumatoid synovial cartilage junction has been investigated. Twelve samples of rheumatoid articular cartilage covered with pannus were examined. Treatment with purified anti-human-monoclonal antibody CDw49a resulted in membrane staining of most of the endothelial cells of the postcapillarly venules in pannus, and of few of the cells infiltrating the synovial tissue and bordering the pannus cartilage junction. When the specimen was treated with purified anti-human-monoclonal antibodies CDw49c anti-(VLA-3), CDw49d anti-(VLA-4) and CDw49e anti-(VLA-5), most of the cells in cartilage pannus junction stained, but there were few staining cells against purified anti-human-monoclonal antibody CDw49b anti-(VLA-2). There were some anti-VLA-l and anti-VLA-5 staining of the chondrocytes at or close to the junction. These results show that the specific adhesion molecules of β1 integrin tested may play a role in rheumatoid pannus formation and increased expression of VLA-3, VLA-4 and VLA-5 at the cartilage pannus junction may represent interaction with matrix protein. Thus VLA molecules stained in the cartilage-pannus junction provide appropriate anchorage, and achieve the variety of immune reaction. Furthermore, the increase in β1 integrin may be necessary for the growth of the pannus and also for the upregulation of the VLA molecules, leading to secondarily to increase attachment.
神戸大学の論文
1994-12-28

β1-Integrin Expression in the Rheumatoid Synovial-Pannus Formation

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