Comparison of apparent Diffusion Coefficients(ADCs)between Two-point and Multi-point Analyses Using High-B-value Diffusion MR Imaging

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We evaluated the accuracy of calculating apparent diffusion coefficients (ADCs)using high-B-value diffusion images. Echo planar diffusion-weighted MR images were obtained at 1.5 tesla in five standard locations in six subjects using gradient strengths corresponding to B values from 0 to 3000 s/mm^2. Estimation of ADCs was made using two methods: a nonlinear regression model using measurements from a full set of B values (multi-point method) and linear estimation using B values of 0 and max only (two-point method). A high correlation between the two methods was noted (r=0.99), and the mean percentage differences were-0.53 % and 0.53 % in phantom and human brain, respectively. These results suggest there is little error in estimating ADCs calculated by the two-point technique using high-B-value diffusion MR images.
公益社団法人日本放射線技術学会の論文
2001-06-20