Hemodynamic Changes with Liver Fibrosis Measured by Dynamic Contrast-Enhanced MRI in the Rat
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概要
- 論文の詳細を見る
Purpose: To evaluate the hemodynamic changes of liver cirrhosis in the rat and investigate the relationship between hemodynamic changes and properties of fibrotic change in the liver. Materials and Methods: Three rats with cirrhosis induced by thioacetamide (TAA), three with disease induced by carbon tetrachloride (CCl4), and three with no treatment were measured on dynamic MRI using a 1.5T scanner. Compartment and moment analysis were used to quantitate hemodynamic changes. Results: Compartment model analysis showed that increased transition speed from vessels to the liver correlated with grade of liver fibrosis. Moment analysis demonstrated that decrease of area under the curve (AUC), mean residence time (MRT), variance of residence time (VRT), half life (T1/2) and increased total clearance (CL) correlated with grade of liver fibrosis. Conclusions: Hemodynamic changes in injured fibrotic liver may be influenced by the grade of fibrosis. Compartment model and moment analysis may be useful for evaluating hemodynamic changes in injured liver.
- 日本磁気共鳴医学会の論文
- 2006-07-10
著者
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ISHIKAWA Makoto
Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus
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Kubo Hitoshi
Department Of Orthopaedic Surgery Kakogawa National Hospital
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Kubo Hitoshi
Department Of Radiologic Technology School Of Health Sciences The University Of Tokushima
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Harada Masafumi
Department of Radiology, School of Medicine, University of Tokushima
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NISHITANI Hiromu
Department of Radiology, School of Medicine, The University of Tokushima
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Harada Masafumi
Department Of Radiologic Technology School Of Health Sciences The University Of Tokushima
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Kubo Hitoshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Nishitani Hiromu
Department Of Radiology Institute Of Health Biosciences The University Of Tokushima Graduate Schoo
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Nishitani Hiromu
Department Of Radiology School Of Medicine The University Of Tokushima
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Harada Masafumi
Department Of Chemistry Faculty Of Science Kyoto University
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Ishikawa Makoto
Laboratory Of Bioenergetics Research Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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