Effect of Cyclooxygenase Inhibitor on Rheumatoid Synovial Fibroblasts Proliferation in Vitro
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概要
- 論文の詳細を見る
In order to examine the antirheumatic effect of nonsteroidal antiinflammatory drugs (NSAIDs), rheumatoid arthritis (RA) synovial fibroblasts were cultured with cyclooxygenase (COX) inhibitor resveratrol (specific for COX-1) or NS-398 (specific for COX-2) in vitro. Resveratol augment cell proliferation, whereas NS-398 suppressed it. Prostaglandin E2 reversed this resveratrol induced cell proliferation to basal level. These results suggested that selective COX-2 inhibitor may inhibit the pannus formation and suppress the progression of RA joint destruction.
- 神戸大学の論文
- 1999-12-26
著者
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MIZUNO Kosaku
Department of Orthopaedic Surgery, Kobe University School of Medicine
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Hirata Soichiro
Faculty of Health Science, Kobe University School of Medicine
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Ishikawa Hitoshi
Faculty of Health Science, Kobe University School of Medicine
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Saura Ryuichi
Faculty of Health Science, Kobe University School of Medicine
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Hirata Soichiro
Faculty Of Health Sciences Kobe University School Of Medicine
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Hirata Soichiro
Faculty Of Health Science Kobe University School Of Medicine
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Ishikawa Hitoshi
Faculty Of Health Sciences Kobe University School Of Medicine
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Ishikawa Hitoshi
School Of Allied Medical Sciences Kobe University
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Ishikawa Hitoshi
Faculty Of Health Science Kobe University School Of Medicine
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Mizuno K
Department Of Orthopedic Surgery Kobe University Graduate School Of Medicine
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Mizuno Kosaku
Department Of Orthopaedic Surgery Kobe University School Of Medicine
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Hirata Soichiro
Department Of Orthopedic Surgery Kobe University School Of Medicine
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Saura R
Faculty Of Health Sciences Kobe University School Of Medicine
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Saura Ryuichi
Faculty Of Health Science Kobe University School Of Medicine
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Saura Ryuuichi
Faculty Of Health Science Kobe University School Of Medicine
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Saura Ryuichi
Kobe University School Of Medicine
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Hirata Souichirou
Faculty Of Health Science Kobe University School Of Medicine
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Ishikawa Hitoshi
Faculty Of Health Science Kobe University
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