A Mechanism of Cisplatin Action : Antineoplastic Effect through Inhibition of Neovascularization
スポンサーリンク
概要
- 論文の詳細を見る
Though cisplatin (cis-diamminedichloroplatinum; CDDP) has been widely used for the treatment of malignant tumors, the mechanism of its action has not been well understood. Neovascularization, which accompanies tumor growth and metastasis, is required for cell proliferation in order to supply both oxygen and nutrients. We have studied in this investigation the effect of CDDP on endothelial cell (EC) proliferation in vitro and on rabbit corneal neovascularization in vivo. DNA synthesis of human umbilical EC was inhibited by CDDP in a dose-dependent fashion. Significant inhibition was observed at concentration over 10(-8) M, which is attainable in the serum of treated patients. Rabbit corneal neovascularization in vivo was also suppressed by intravenous injection of 0.5 mg/kg of CDDP for 10 days. These results suggest that CDDP might have an indirect anti-neoplastic effect through the suppression of neovascularization required for the tumor growth.
- 神戸大学の論文
著者
-
MIZUNO Kosaku
Department of Orthopaedic Surgery, Kobe University School of Medicine
-
Saura Ryuichi
Department of Orthopaedic Surgery, Kobe University School of Medicine
-
MATSUBARA Tsukasa
Matsubara Mayflower Hospital
-
Matsubara Tsukasa
Matsubara Clinic
-
Mizuno Kosaku
Department Of Orthopaedic Surgery Kobe University School Of Medicine
-
Mizuno Kosaku
Department Of Orthopedic Surgery Kobe University School Of Medicine
-
Saura Ryuichi
Department Of Orthopaedic Surgery Kobe University School Of Medicine
-
Saura Ryuuichi
Faculty Of Health Science Kobe University School Of Medicine
-
Yoshikawa Atsushi
Department Of Computational Intelligence And Systems Science Tokyo Institute Of Technology
-
Saura Ryuichi
Kobe University School Of Medicine
-
Yoshikawa Atsushi
Department Of Orthopedic Surgery Kobe University School Of Medicine
関連論文
- How Do Customers Move in a Supermarket? : Analysis by Real Observation and Agent Simulation
- Dedifferentiated liposarcoma with chondroblastic osteosarcomatous dedifferentiation
- Anaplastic osteosarcoma with abundant eosinophilic cytoplasm and minimal osteoid production
- Solitary infantile myofibromatosis in the femur
- Apoptosis of hypertrophic chondrocytes in rat cartilaginous growth plate
- Inhibiton of Thrombin-induced Cartilage Proteoglycan Release by Argatroban
- Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis
- Osteochondritis of Hallux Sesamoid Bone : A Case Report
- Adenocarcinoma of the Prostate Presenting Initially as Intraspinal Tumors
- A Locked knee Due To A Large Nodule of Pigmented Villonodular Synovitis in Patello-Femoral Joint
- Posterior Interosseous Radial Nerve Neuropathy at the Arcade of Frohse
- Recurrent Lateral Subdislocation of the Tendon of the Long Biceps Brachii
- Vascular Injury from Intrapelvic Migration of a Screw Used for the Intertrochanteric Fracture
- Bilateral Radial Nerve Palsies due to Sustained Physical Trauma
- Long-Term Follow-up of a Patient with Congenital Sensory Neuropathy
- Sacral Radiculopathy Secondary to Multicentric Osteosarcoma
- Inter-relation between Variables of Physical Disability in Postoperative Patients with Adult Hip Disorders : A Statistical Approach
- Social Networks of Members of Software Development Projects
- Ambulatory Physical Activity is Associated with Walking Speed in Adult Women with Hip Disorders
- Low intensity pulsed ultrasound exposure increases prostaglandin E_2 release in human dermal fibroblasts
- Age- and Speed-Related Changes in Gait Parameters of Adult Women with Osteoarthritis of the Hip
- A Hip Pain Caused from Labral Tears Associated with Intraosseous Ganglion of Acetabulum in a Patient with Mild Hip Osteoarthrosis
- Nitric oxide synthesis of bovine articular chondrocytes induced by thrombin not through the thrombin receptor, protease-activated receptor-1 (PAR-1)
- Inhibition of DNA Duplication of Rheumatoid Synovial Fibroblast by N'-[β-D-Ribofuranosyl]-5-hydroxyimidazol-4-carboxamide, Mizoribine
- An immunohistochemical and immunoelectron microscopic study of beta integrins (α4β1, α5β1) and matrix metalloproteinases expression in rheumatoid synovial pannus formation in rheumatoid arthritis
- Aneurysmal Bone Cyst Arising From a Giant Cell Tumor of the Calcaneus
- Beta Integrins (α4β1, α5β1) and Matrix Metalloproteinases Expression in Synovial Pannus Formation in Rheumatoid Arthritis
- Effect of Prostaglandin E_2 and EP Receptor Agonists on Cell Proliferation and Basic Fibroblast Growth Factor Synthesis of Rheumatoid Synovial Fibroblasts in Vitro
- A Rheumatoid Nodule on the Extensor Tendon of the Wrist
- Arthritis Caused by Chlamydia in Reiter Syndrome : A Case Report of Long-term Follow Up
- Effect of Cyclooxygenase Inhibitor on Rheumatoid Synovial Fibroblasts Proliferation in Vitro
- Different Myoelectric Behavior of the Erector Spinae in Flexion and Reextension During Trunk Foward Bending
- Multicentric Reticulohistiocytosis : A Case Report of Twenty Years Follow Up
- The Effect of Activities of Daily Living (ADL) Instructions to Rheumatoid Arthritis Patients
- Lumbopelvic Movemement Interaction During Trunk Forward Bending in Healthy Young Adults
- Interaction of VLA-5 Molecule With Rheumatoid Articular Cartilage Surface : An Electron Microscopic Evidence of Expression of VLA-5 on Pannus Invading Cells
- Chronic Osteomyelitis of the Proximal Femur in SAPHO Syndrome with Avascular Necrosis of the Femoral Head : A Case Report
- BMP-3 mRNA Expression during Endochondral Ossification of Mouse Bone Tissue
- Modulation of Osteonectin and Osteopontin Expression during Fracture Healing of Mouse Bone Tissue
- Effect of Hyaluronic Acid on Proteoglycan Metabolism in Cultured Bovine Articular Chondrocytes
- Ulnar Bursa Distention Following Volar Subluxation of the Distal Radioulnar Joint After Distal Radial Fracture : A Rare Cause of Carpal Tunnel Syndrome
- Identification of Voting with the Feet through Agent-Based Modeling
- Cytokine Enhancements of Monocyte Attachment on the Surface of Cartilage: A Possible Trigerring Factors of Pannus Formation in Arthritis
- A Mechanism of Cisplatin Action : Antineoplastic Effect through Inhibition of Neovascularization
- The Effect of Lipid Peroxide on Osteoblasts and Vascular Endothelial Cells : The Possible Role of Ischemia-Reperfusion in the Progression of Avascular Necrosis of the Femoral Head
- Total Hip Arthroplasty with Chiari Pelvic Osteotomy in Dysplastic Hips
- Acetabular Reconstruction Using Protrusio Acetabli (PA) Socket in Revision Total Hip Arthroplasty
- Bipolar Hip Arthroplasty for Osteoarthritis of the Hip Joint
- Rheumatoid pannus formation: synovial cell attachment to the surface of cartilage
- Prostaglandin E2 regulates the expression of basic fibroblast growth factor messenger RNA in normal human fibroblasts
- Immunolocalization of cytokines and growth factors in subacrominal bursa of rotator cuff tear patients
- Three-Dimensional Collagen Gel Culture Promotes Osteoblastic Phenotype in Bone Marrow Derived Cells
- Expression of Adhesion Molecules in the Lymphoid Cell Distribution in Rheumatoid Synovial Membrane
- Role of fracture hematoma and periosteum during fracture healing in rats : interaction of fracture hematoma and the periosteum in the initial step of the healing process
- The antiproliferative effect of mizoribine on rheumatoid synovial fibroblast mediated by induction of apoptosis
- Effect of nitric oxide on mouse clonal osteogenic cell, MC3T3-E1, proliferation in vitro
- Effects of Subthreshold Transcranial Magnetic Stimulation on Choice Reaction Time and Correlation with Motor Cortical Activation
- Treatment Femoral Neck and Trochanteric Fractures
- Localization of Synaptotagmin in the Regenerating Sprouts Emanating from the Nodes of Ranvier
- Which vertebrae should be assessed in diagnosing osteoporosis by plain radiography?Comparative study of radiographic findings and bone mineral density measured by dual energy X-ray absorptiometry
- Effect of prostsglandin e_2 on nitric oxide synthesis in articular chondrocytes
- Posterior Release Surgery for Severe Flexion Contracture of the knee in Patients with Rheumatoid Arthritis
- Effect of Substance-P on Metalloproteinase Release and Extracellular Matrix Accumulation of Articular Chondrocytes
- The Role of Cyclooxygenase-2 in Lumbar Disc Herniation
- Intervertebral disc cell apoptosis by nitric oxide : biological understanding of intervertebral disc degeneration
- Treatment of Osteoporosis : With Special Reference to the Coexistence of Osteoporosis and Osteomalacia
- Possible Roles lnterleukin-1 and Collagenase in the Pannus Formation in Rheumatoid Arthritis
- Development of Agent-Based In-Store Simulator to Analyze Pedestrian Behaviors
- Magnetic Resonance Imaging of Syringomyelia
- Abstract aspects of asymptotic analysis
- Functional Fracture Bracing, by Augusto Sarmiento and Loren L. Latta : Philadelphia : Lippincott, Williams and Wilkins, 2002, 0-7817-3729-X
- Inhibitory Effect of c-fos Overexpression on B Cell Proliferative Responses to Membrane IgM Cross-Linking
- Analysis of Success Factors of IT Projects Based on Social Network Theory
- On Some Further Properties of Solutions to a Certain Semi-linear System of Partial Differential Equations
- The course of the Japanese Orthopaedic Association in the twentieth century and into the future
- Preoperative insulin secretion ability and pancreatic parenchymal thickness as useful parameters for predicting postoperative insulin secretion in patients undergoing pancreaticoduodenectomy
- Discontinuation of adalimumab treatment in rheumatoid arthritis patients after achieving low disease activity
- Analysis of perioperative clinical features and complications after orthopaedic surgery in rheumatoid arthritis patients treated with tocilizumab in a real-world setting : results from the multicentre TOcilizumab in Perioperative Period (TOPP) study