Inhibitory Effect of c-fos Overexpression on B Cell Proliferative Responses to Membrane IgM Cross-Linking
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概要
- 論文の詳細を見る
Constitutive expression of the c-fos gene perturbs the de novo synthesis of RNA and DNA in B cells stimulated by surface immunoglobulin (sIg) cross-linking. In order to examine kinetics of the regulatory effect on the activation process of B cells, we used splenic B cells from transgenic mice carrying the c-fos gene under the control of the interferon alpha/beta (IFN)-inducible Mx gene promoter (Mx-c-fos). In the absence of IFN, Mx-c-fos B cells proliferated well by anti-IgM stimulation. However, both RNA and DNA synthesis in the Mx-c-fos B cells were markedly reduced by the addition of IFN in the culture within 12 h after anti-IgM stimulation. These results suggest that this regulatory effect of c-Fos displays at the mid G1 phase of the cell cycle.
- 神戸大学の論文
著者
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Mizuno K
Department Of Orthopedic Surgery Kobe University Graduate School Of Medicine
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Mizuno Kosaku
Department Of Orthopaedic Surgery Kobe University School Of Medicine
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Koizumi Tamio
Hyogo Institute For Clinical Research
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Tomita Yoshitaka
Department of Orthopedic Surgery, Kobe University School of Medicine
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Tomita Yoshitaka
Department Of Orthopedic Surgery Kobe University School Of Medicine
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Koizumi T
Hyogo Institute Of Clinical Research
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