The Effect of the Small and Unstable Autologous Osteochondral Graft on Repairing the Full-Thickness Large Articular Cartilage Defect in a Rabbit Model

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概要

• 論文の詳細を見る

• We have investigated the effect of the insufficient autologous osteochondral graft onhealing of the large articular cartilage defect using a rabbit model. An osteochondraldefect, 7 mm in diameter, was made on the patellar groove of the femoral condyle andrepaired with two surgical procedures: Group I, the osteochondral fragment as half asthe defect was grafted. The graft was unstable and the size of the graft was smallerthan the defect. This is a model of the insufficient autologous osteochondral graft to thelarge articular cartilage defect; Group II, the defect was left empty. At 2, 4, 12, and 24weeks after the surgery, the specimens were analyzed macroscopically and histologically.To evaluate the microscopic morphology, a histologic grading scale composed of 5categories was used. In Group I, although the graft sank a little, a grafted cartilagesurvived and the reparative fibrous tissue filled the defect covering implanted cartilage.In contrast, in Group II, the defect was only partially covered by fibrocartilaginoustissue with a faintly staining matrix. Throughout the entire observed periods, the scoresof the repaired cartilage in Group I are significantly higher than those in Group II.Even the half size of osteochondral graft has an effect to reduce the size of the cartilagedefect such as the spacer and leads to better healing compared to the cartilage defectuntreated. In case that it is hard to transplant an optimal osteochondral graft becauseof large cartilage lesion, even the small and unstable osteochondral plug should betransplanted.

• 神戸大学の論文

著者

• Makino Takeshi

  Department Of Orthopedic Surgery Kobe University Graduate School Of Medicine

• Makino Takeshi

  神戸大学 医学系研究科整形外科学

• Yoshiya Shinichi

  Hyogo Coll. Of Medicine Nishinomiya Jpn

• Yohsiya Shinichi

  Department Of Orthopaedic Surgery Hyogo College Of Medicine

• Yoshiya S

  神戸大学医学系研究科

• Yoshiya Shinichi

  Department Of Orthopaedic Surgery Hyogo College Of Medicine

• Yoshiya Shinichi

  Department Of Orthopedic Surgery Institute For Advanced Medical Sciences Hyogo College Of Medicine

• Fujioka Hiroyuki

  Department Of Orthopedic Surgery Kobe University Graduate School Of Medicine

• Fujioka H

  Institute For Solid State Physics University Of Tokyo

• Kurosaka Masahiro

  Department of Orthopedic Surgery, Kobe University Graduate School of Medicine

• Fujioka Hiroyuki

  Department Of Electrical And Electronic Engineering Kanagawa Institute Of Technology

• MATSUI Nobuzo

  Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine

• Terunkina Mitsunobu

  Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine

• Yoshiya Shinichi

  Department Of Orthopaedic Surgery Kobe University Graduate School Of Medicine

• Matsui N

  Department Of Orthopaedic Surgery Kobe University Graduate School Of Medicine

• Matsui Nobuzo

  Department Of Orthopaedic Surgery Kobe University School Of Medicine

• Mizuno K

  Department Of Orthopedic Surgery Kobe University Graduate School Of Medicine

• Fujioka Hiroyuki

  Department Of Orthopaedic Surgery Kobe University Graduate School Of Medicine

• Kurosaka Masahiro

  Department Of Orthopaedic Surgery Kobe University Graduate School Of Medicine

• Terunkina Mitsunobu

  Department Of Orthopaedic Surgery Kobe University Graduate School Of Medicine

• Futani Hiroyuki

  Department Of Orthopedic Surgery Institute For Advanced Medical Sciences Hyogo College Of Medicine

• Kurosaka Masahiro

  Department Of Orthopaedic Surgery Kobe University Faculty Of Medicine

• Fujioka Hiroyuki

  Department Of Orthopaedic Surgery Hyogo College Of Medicine

• Kurosaka Masahiro

  Kobe Univ. Graduate School Of Medicine

• Terukina Mitsunobu

  Department Of Orthopaedic Surgery Kobe University School Of Medicine

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