Immunolocalization of cytokines and growth factors in subacrominal bursa of rotator cuff tear patients
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概要
- 論文の詳細を見る
Inflammation in the subacromial bursa causes pain in patients suffering from rotator cuff tear,with this long-lasting inflammation leading to fibrosis and thickening of the subacromial bursa. Bothinflammatory cytokines and mechanical stress, and impingement in the subacromial space, might induceand worsen this inflammation. However, little is known of the mechanism of this inflammation. In thisstudy, we used immunohistological staining to demonstrate the expression of Interleukin-1 (IL-1 ),Tumor necrosis factor (TNF- ), transforming growth factor (TGF- ), and basic fibroblast growthfactor (bFGF) in subacromial bursa derived from the patients suffering from rotator cuff tear. On the otherhand the expression of these inflamnlatory cytokines and growth factors were little detected only to asmall degree in patients with anterior shoulder instability who did not have severe shoulder pain andimpingement in the subacromial space. Our findings suggest that those inflammatory cytokines andgrowth factors may play an important role in inflammation of the subacromial bursa. Controling theexpression of these cytokines and growth factors might be important for treating patients suffering fromshoulder pain due to rotator cuff tear.
- 神戸大学の論文
著者
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Sakai Yoshitada
Department Of Orthopaedic Surgery Kobe University School Of Medicine
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Sakai Yoshitada
Department Of Medicine And The Center For Rheumatic Diseases Kobe University Hospital
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Fujita Kenji
Department Of Orthopaedic Surgery Kobe University School Of Medicine
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Mizuno K
Department Of Orthopedic Surgery Kobe University Graduate School Of Medicine
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Mizuno Kosaku
Department Of Orthopaedic Surgery Kobe University School Of Medicine
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Sakai Hiroshige
Department of Orthopaedic Surgery, Kobe University School of Medicine
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Sakai H
Department Of Orthopaedic Surgery Kobe University School Of Medicine
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Sakai Hiroshige
Department Of Food Science And Technology Faculty Of Bioindustry Tokyo University Of Agriculture
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