Multicentric Reticulohistiocytosis : A Case Report of Twenty Years Follow Up

概要

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We describe a 42-year old women with over a twenty-year history of arthritis mutilans-like destructive joint changes and with two year history of nodules on the fingers, ears, face and eyelid. She was suspected as having rheumatoid arthritis, however, biopsies from the nodules and synovial membrane of the knee joint revealed multicentric reticulohistiocytosis. Histology of the both lesions disclosed an infiltrate composed primarily of histiocytic cells. The radiographic features of the case were most marked in the interphalangeal joints of the hands. Very little osteoporosis was evident despite the marked destruction. The whole process resembles an arthritis mutilans. She had been treated by using gold sodium thiomalate over 20-years. To our knowledge it has not been used previously to multicentric reticulohistiocytosis. She has been long term remission with gold treatment. We are continuing the treatment and follow up the patient.
神戸大学の論文
1998-12-26