Relationship between Serum β-Cryptoxanthin and Circulating Bone Metabolic Markers in Healthy Individuals with the Intake of Juice (Citrus unshiu) Containing β-Cryptoxanthin
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概要
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The relationship between the serum β-cryptoxanthin concentration and circulating biochemical markers of bone metabolism in healthy individuals with the intake of juice prepared from Satsuma mandarin (Citrus unshiu MARC.) containing β-cryptoxanthin was investigated. Twenty volunteers (10 men and ten women) were divided into two groups of 10 volunteers (5 men and 5 women) each, and each group was sequentially given juice (192ml) containing two different amounts of β-cryptoxanthin once a day for 56 days as follows : either regular juice with naturally occurring β-cryptoxanthin 802μg/100ml or reinforced juice containing β-cryptoxanthin 1500μg/100ml. γ-Car-boxylated osteocalcin, which is a marker of bone formation, and bone tartrate-resistant acid phosphatase (TRAP), which is a marker of bone resorption, were assayed. The serum β-cryptoxanthin concentration was significantly increased with the intake of regular juice for 56 days. This increase was significantly enhanced by the intake of β-cryptoxanthin-reinforced juice. The intake of regular juice or of β-cryptoxanthin-reinforced juice for 56 days caused a significant increase in serum γ-carboxylated osteocalcin and a significant decrease in serum bone TRAP activity. A positive relationship between serum β-cryptoxanthin and circulating γ-carboxylated osteocalcin concentrations was found using the value obtained from all groups for before intake and with the intake of regular juice and β-cryptoxanthin-reinforced juice. A negative relationship between serum β-cryptoxanthin concentration and circulating TRAP activity was observed. This study shows that a relationship between serum β-cryptoxanthin and circulating bone metabolic markers is found in healthy individuals with the intake of juice containing β-cryptoxanthin.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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YAMAGUCHI Masayoshi
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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IGARASHI Aki
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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Sugawara Kuniaki
Research & Development, Ehime Beverage, Inc.
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Sumida Takashi
Research & Development, Ehime Beverage, Inc.
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Morita Seiichi
Research & Development, Ehime Beverage, Inc.
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Igarashi A
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Igarashi Aki
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Sumida Takashi
Research & Development Ehime Beverage Inc.
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Sumida Takashi
Ehime Federation Of Agricultural Cooperative Associations
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Morita Seiichi
Research & Development Ehime Beverage Inc.
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Yamaguchi M
Univ. Shizuoka Sizuoka Jpn
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Sugawara Kuniaki
Research & Development Ehime Beverage Inc.
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Yamaguchi Masayoshi
Laboratories Of Metabolism And Endocrinology School Of Food And Nutritional Sciences The University
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