Prolonged Intake of Juice (Citrus Unshiu) Reinforced with β-Crypthoxanthin Has an Effect on Circulating Bone Biochemical Markers in Normal Individuals
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概要
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A change in circulating biochemical markers of bone metabolism in normal individuals with the intake of juice prepared from Satsuma mandarin (Citrus unshiu MARC.) containing β-crypthoxanthin was investigated. Twentyone volunteers (ten males and eleven females) were divided into two groups of ten volunteers (five males and five females) and eleven volunteers (five males and six females), and each group was given sequentially juice (192 ml) containing two different contents of β-crypthoxanthin once a day for 28 or 56 days as follows : either regular juice with naturally occurring 802 μg β-cryptoxanthin/100 ml or a reinforced juice containing 1500 μg β-cryptoxanthin/100 ml. As serum bone markers, bone-specific alkaline phosphatase, γ-carboxylated osteocalcin, bone tartrate-resistant acid phosphatase (TRAP), and N-telopeptide of type I collagen were assayed. The intake of regular juice for 28 or 56 days caused a significant increase in γ-carboxylated osteocalcin, a marker of bone formation, and the intake for 56 days produced a significant decrease in serum bone TRAP activity. Moreover, intake of the β-cryptoxanthin reinforced juice for 28 or 56 days caused a significant increase in serum β-carboxylated osteocalcin concentration and a corresponding decrease in serum bone TRAP activity and N-telopeptide of type I collagen, a marker of bone resorption. This study suggests that the intake of β-cryptoxanthin reinforced juice has a stimulatory effect on bone formation and an inhibitory effect on bone resorption in normal individuals.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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YAMAGUCHI Masayoshi
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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IGARASHI Aki
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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Uchiyama Satoshi
Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, Unive
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Sugawara Kuniaki
Research & Development, Ehime Beverage, Inc.
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Sumida Takashi
Research & Development, Ehime Beverage, Inc.
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Morita Seiichi
Research & Development, Ehime Beverage, Inc.
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Igarashi A
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Igarashi Aki
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Sumida Takashi
Research & Development Ehime Beverage Inc.
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Sumida Takashi
Ehime Federation Of Agricultural Cooperative Associations
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Morita Seiichi
Research & Development Ehime Beverage Inc.
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Yamaguchi M
Univ. Shizuoka Sizuoka Jpn
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Sugawara Kuniaki
Research & Development Ehime Beverage Inc.
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Uchiyama Satoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Uchiyama Satoshi
Laboratory Of Biology Faculty Of Education And Human Sciences Niigata University
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Yamaguchi Masayoshi
Laboratory Of Endocrinology And Molecular Metabolism Graduate School Of Nutritional Sciences Univers
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Yamaguchi Masayoshi
Laboratories Of Metabolism And Endocrinology School Of Food And Nutritional Sciences The University
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